1073266-02-0
- Product Name：trans-4-Trifluoromethyl-cyclohexylamine
- Molecular Formula：C7H12F3N
- Purity：99%
- Molecular Weight：167.174
Product Details;
CasNo： 1073266-02-0
Molecular Formula： C7H12F3N
Factory Supply Hot Sale trans-4-Trifluoromethyl-cyclohexylamine 1073266-02-0 In Bulk Supply
- Molecular Formula:C7H12F3N
- Molecular Weight:167.174
- Refractive Index:1.4040 to 1.4080
- Boiling Point:145.1±35.0 °C(Predicted)
- PKA:10.29±0.70(Predicted)
- PSA：26.02000
- Density:1.136±0.06 g/cm3(Predicted)
- LogP:2.76650
1073266-02-0 Relevant articles
Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease
Harrison, Justin R.,Sarkar, Sandipan,Hampton, Shahienaz,Riley, Jennifer,Stojanovski, Laste,Sahlberg, Christer,Appelqvist, Pia,Erath, Jessey,Mathan, Vinodhini,Rodriguez, Ana,Kaiser, Marcel,Pacanowska, Dolores Gonzalez,Read, Kevin D.,Johansson, Nils Gunnar,Gilbert, Ian H.
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Chagas disease is caused by the protozoa...
Aliphatic C-H Bond Oxidation with Hydrogen Peroxide Catalyzed by Manganese Complexes: Directing Selectivity through Torsional Effects
Milan, Michela,Bietti, Massimo,Costas, Miquel
, p. 2720 - 2723 (2018/05/22)
Substituted N-cyclohexyl amides undergo ...
PYRROLO[2,3-C]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE
-
, (2018/08/03)
Disclosed are a pyrrolo[2,3-c]pyridine d...
An improved synthesis of 2-, 3-, and 4-(trifluoromethyl)cyclohexylamines
Alekseenko, Anatoliy N.,Denis, Klukovsky,Lukin, Oleg,Mykhailiuk, Pavel K.,Shishkin, Oleg V.,Pustovit, Yurii M.
, p. 2739 - 2742 (2012/11/07)
An improved synthesis of 2-, 3-, and 4-t...
1073266-02-0 Process route
-
-
75091-99-5
4-(trifluoromethyl)cyclohexan-1-one
-
-
1073266-02-0
trans-4-(trifluoromethyl)cyclohexane-1-amine
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; pyridine / ethanol / 5 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux
With
pyridine; lithium aluminium tetrahydride; hydroxylamine hydrochloride;
In
tetrahydrofuran; ethanol;
|
|
|
Multi-step reaction with 2 steps
1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h / 25 °C
2: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethanol / 16 h / 25 °C
With
palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride;
In
tetrahydrofuran; ethanol;
|
|
|
Multi-step reaction with 3 steps
1.1: methanol / 20 °C / Molecular sieve
1.2: 4.5 h / 0 - 20 °C / Molecular sieve
2.1: ammonia / methanol; dichloromethane / Resolution of racemate
3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 48 h / 20 °C
With
palladium on activated charcoal; ammonia; hydrogen;
In
tetrahydrofuran; methanol; dichloromethane;
|
-
-
N-benzyl-4-(trifluoromethyl)cyclohexane-1-amine
-
-
1073266-02-0
trans-4-(trifluoromethyl)cyclohexane-1-amine
| Conditions | Yield |
|---|---|
|
With
palladium on activated charcoal; hydrogen;
In
tetrahydrofuran; ethanol;
at 25 ℃;
for 16h;
|
2 g |
|
With
palladium on activated charcoal; hydrogen;
In
tetrahydrofuran;
at 20 ℃;
for 48h;
|
1073266-02-0 Upstream products
-
455-14-1
4-trifluoromethylphenylamine
-
75091-99-5
4-(trifluoromethyl)cyclohexan-1-one
-
75092-01-2
4-trifluoromethylcyclohexanone oxime
-
1087351-23-2
benzyl-(4-trifluoromethylcyclohexyl)amine
1073266-02-0 Downstream products
-
1360624-52-7
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(difluoromethoxy)-5-amino-4-nitro-benzoic acid amide
-
1380648-47-4
N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide
-
1360622-19-0
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(difluoromethoxy)-1H-benzimidazole-5-carboxylic acid amide
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