What is the Medroxyprogesterone 17-acetate?

Medroxyprogesterone 17-acetate is white crystalline powder, while it's Molecular Formula is C24H34O4. white crystalline powder Medroxyprogesterone Acetate is a synthetic progesterone receptor agonist that is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding.

What is the CAS number for Medroxyprogesterone 17-acetate?

The CAS number of Medroxyprogesterone 17-acetate is 71-58-9.

What is Medroxyprogesterone 17-acetate (71-58-9) used for?

Medroxyprogesterone 17-acetate is a synthetic progestogen.,, It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation. Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus. It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity. Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts., Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.InChI:InChI=1/C24H34O4/c1-13-10-17-18(23(4)8-6-16(27)11-19(13)23)7-9-24(5)20(17)12-21(28-15(3)26)22(24)14(2)25/h11,13,17-18,20-22H,6-10,12H2,1-5H3

What is the Medroxyprogesterone 17-acetate?

Medroxyprogesterone 17-acetate is white crystalline powder, while it's Molecular Formula is C24H34O4. white crystalline powder Medroxyprogesterone Acetate is a synthetic progesterone receptor agonist that is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding.

What is the CAS number for Medroxyprogesterone 17-acetate?

The CAS number of Medroxyprogesterone 17-acetate is 71-58-9.

What is Medroxyprogesterone 17-acetate (71-58-9) used for?

Medroxyprogesterone 17-acetate is a synthetic progestogen.,, It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation. Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus. It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity. Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts., Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.InChI:InChI=1/C24H34O4/c1-13-10-17-18(23(4)8-6-16(27)11-19(13)23)7-9-24(5)20(17)12-21(28-15(3)26)22(24)14(2)25/h11,13,17-18,20-22H,6-10,12H2,1-5H3

Product classification

Hormones and steriods major pro

Medroxyprogesterone acetate intermediates

Progesterone intermediate

Cyproterone acetate intermediate

Deflazacort intermediate

Desogestrel intermediate

Finasteride intermediate
Major Products

Rocuronium bromide intermediate

Ubrogepant intermediate

Rimegepant intermediate

Indacaterol intermedaite

Dapagliflozin intermediate
Others

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71-58-9

Product Name：Medroxyprogesterone Acetate
Molecular Formula：C₂₄H₃₄O₄
Purity：99%
Molecular Weight：386.532

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Product Details;

CasNo： 71-58-9

Molecular Formula： C₂₄H₃₄O₄

Appearance： white crystalline powder

Buy High Quality High Purity 99% Medroxyprogesterone Acetate 71-58-9 Best Price

Molecular Formula:C24H34O4
Molecular Weight:386.532
Appearance/Colour:white crystalline powder
Vapor Pressure:3.85E-10mmHg at 25°C
Melting Point:206-207 °C(lit.)
Refractive Index:48 ° (C=1, Dioxane)
Boiling Point:496.4 °C at 760 mmHg
Flash Point:213.2 °C
PSA：60.44000
Density:1.13 g/cm³
LogP:4.51270

Medroxyprogesterone 17-acetate(Cas 71-58-9) Usage

Description

Medroxyprogesterone acetate (MPA) is an odorless, white to off-white microcrystalline powder, and a synthetic derivative of the sex hormone progesterone.

Uses

Medroxyprogesterone acetate (MPA) serves multiple roles including a contraceptive, hormone replacement therapy, and treatment for endometriosis. MPA effectively prevents fertilization and accelerates egg transport in female ferrets when administered before ovulation, and reversibly blocks ovulation in rats. It exhibits anti-androgenic and immunosuppressive properties and has been utilized to treat various conditions such as dysfunctional uterine bleeding, secondary amenorrhea, and certain carcinomas. MPA is also used in veterinary medicine to manage sexually dimorphic behavior in cats. Despite its clinical benefits, it is a suspected carcinogen with various human and experimental adverse effects reported, including reproductive and teratogenic impacts. MPA is sensitive to air and light and needs protection to maintain its stability.

InChI:InChI=1/C24H34O4/c1-13-10-17-18(23(4)8-6-16(27)11-19(13)23)7-9-24(5)20(17)12-21(28-15(3)26)22(24)14(2)25/h11,13,17-18,20-22H,6-10,12H2,1-5H3

71-58-9 Relevant articles

Preparation method of medroxyprogesterone acetate for perimenopausal syndrome

-

, (2022/03/17)

The invention relates to a preparation m...

Use of medroxyprogesterone acetate for hormone therapy in postmenopausal women: Is it safe?

Frank Z. Stanczyk a c, Bhagu R. Bhavnani b

The Journal of Steroid Biochemistry and Molecular Biology Volume 142, July 2014, Pages 30-38

The negative results of large clinical studies employing combined HT with medroxyprogesterone acetate and CEE in postmenopausal women has called into question the safety of medroxyprogesterone acetate. This review examines the pharmacokinetics and metabolism of medroxyprogesterone acetate, which can be altered by a variety of factors in the age group of women using HT to produce potential changes in potency. It also looks at the effects of MPA on the breast, cardiovascular system, and brain, to examine whether there is evidence for an increase in risk of diseases

Oral Medroxyprogesterone Acetate and Combination Oral Contraceptives for Acute Uterine Bleeding A Randomized Controlled Trial

Munro, Malcolm G. MD1,3; Mainor, Nakia MD1; Basu, Romie MD1; Brisinger, Mikael MD2; Barreda, Lorena1

Obstetrics & Gynecology 108(4):p 924-929, October 2006.

Forty patients were randomly assigned, 20 in each group; 33 were evaluated at the 14-day visit. Emergency surgical procedures were avoided in 100% of those women taking medroxyprogesterone acetate and 95% of the OC group. Cessation of bleeding had occurred in 88% of the OC group and 76% of those receiving medroxyprogesterone acetate, with a median time to bleeding cessation of 3 days for both groups. Compliance with therapy was higher in the medroxyprogesterone acetate group than the OC group, but there was no overall difference in the incidence of treatment-related nausea and bloating.

71-58-9 Process route

: 32634-95-0
17α-Acetoxy-6-methylene-pregn-4-ene-3,20-dione

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With ethanol; 5%-palladium/activated carbon; In cyclohexene; at 75 - 78 ℃; for 5h; Reagent/catalyst; Temperature;	87.5%
With sodium acetate; cyclohexene; palladium on activated charcoal; In ethanol; water; Heating / reflux;