137234-71-0
- Product Name：(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-camphorsulfonate
- Molecular Formula：C16H14F3N5O
- Purity：99%
- Molecular Weight：581.616
Product Details;
CasNo： 137234-71-0
Molecular Formula： C16H14F3N5O
Buy High Quality High Purity (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-camphorsulfonate 137234-71-0 Competitive Price
- Molecular Formula:C10H16O4S*C16H14F3N5O
- Molecular Weight:581.616
- Vapor Pressure:3.63E-11mmHg at 25°C
- Melting Point:127-130℃
- Refractive Index:1.616
- Boiling Point:508.6°C at 760 mmHg
- Flash Point:261.4°C
- PSA：156.54000
- Density:1.42g/cm3
- LogP:4.52730
Voriconazole(Cas 137234-71-0) Usage
InChI:InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3
137234-71-0 Relevant articles
Voriconazole synthesis method
-
Paragraph 0011; 0048; 0064-0075, (2020/08/02)
The invention relates to a voriconazole ...
PROCESS FOR THE PREPARATION OF VORICONAZOLE
-
Page/Page column 10, (2012/01/13)
The present invention provides a process...
PROCESS FOR PREPARING VORICONAZOLE BY USING NEW INTERMEDIATES
-
Page/Page column 14, (2011/09/14)
Provided is a process for preparing Vori...
PROCESS FOR THE PREPARATION OF VORICONAZOLE
-
Page/Page column 5, (2010/04/23)
The present invention relates to an impr...
137234-71-0 Process route
-
-
35963-20-3,61380-66-3
(R)-10-camphorsulfonic acid
-
-
137234-63-0,173967-54-9,188416-29-7
2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol
-
-
188416-34-4,137234-71-0
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
| Conditions | Yield |
|---|---|
|
In
methanol;
at 21 - 50 ℃;
for 2.25h;
Product distribution / selectivity;
|
59.11% |
|
In
methanol; ethyl acetate;
Product distribution / selectivity;
Heating / reflux;
|
97.15 % ee |
|
In
methanol;
at 22 - 55 ℃;
for 2h;
|
|
|
In
methanol; ethyl acetate;
at 20 - 23 ℃;
Product distribution / selectivity;
Heating / reflux;
|
99.41 % ee |
|
In
methanol;
at 23 - 25 ℃;
for 2h;
Product distribution / selectivity;
Heating / reflux;
|
93.87 % ee |
|
In
methanol; acetone;
at -20 - 25 ℃;
for 15h;
|
|
|
In
methanol; acetone;
Reflux;
|
12.3 g |
-
-
35963-20-3,61380-66-3
(R)-10-camphorsulfonic acid
-
-
182230-43-9,137234-63-0,173967-54-9,188416-29-7
2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
-
-
188416-34-4,137234-71-0
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
| Conditions | Yield |
|---|---|
|
In
methanol;
at 0 - 2 ℃;
Product distribution / selectivity;
|
81.52% |
|
In
acetone;
at 45 - 55 ℃;
for 2h;
Large scale;
|
70% |
|
In
methanol; acetone;
for 1h;
Reflux;
|
40% |
137234-71-0 Upstream products
-
35963-20-3
(R)-10-camphorsulfonic acid
-
137234-63-0
2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol
-
137234-62-9
voriconazole
-
182230-43-9
2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
137234-71-0 Downstream products
-
137234-62-9
voriconazole
-
35963-20-3
(R)-10-camphorsulfonic acid
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