54556-98-8

Description

Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.

Chemical Properties

Off-White Solid

Originator

Apogepha (Germany)

Uses

Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.

Brand name

Mictonorm; Mictonetten

General Description

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Biochem/physiol Actions

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Clinical Use

Treatment of urinary frequency, urgency and incontinence Neurogenic bladder instability

Drug interactions

Potentially hazardous interactions with other drugs Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Metabolism

Propiverine is extensively metabolised by intestinal and hepatic enzymes. Four metabolites were identified in urine; two of them are pharmacologically active and may contribute to the therapeutic efficacy. Propiverine and its metabolites are excreted in the urine, bile and faeces.