160969-03-9

  • Product Name:2-[2-(2,2,2-trifluoroethoxy)phenoxy]-Ethanol,1-methanesulfonate
  • Molecular Formula:C11H13F3O5S
  • Purity:99%
  • Molecular Weight:314.282
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Product Details;

CasNo: 160969-03-9

Molecular Formula: C11H13F3O5S

Appearance: colorless or light yellow liquid

Chinese Factory Supply 99% Pure 2-[2-(2,2,2-trifluoroethoxy)phenoxy]-Ethanol,1-methanesulfonate 160969-03-9 In Stock

  • Molecular Formula:C11H13F3O5S
  • Molecular Weight:314.282
  • Appearance/Colour:colorless or light yellow liquid 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:52.0 to 56.0 °C 
  • Refractive Index:1.469 
  • Boiling Point:396.401 °C at 760 mmHg 
  • Flash Point:193.537 °C 
  • PSA:70.21000 
  • Density:1.362 g/cm3 
  • LogP:3.06350 

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate(Cas 160969-03-9) Usage

Uses

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.

InChI:InChI=1/C11H13F3O5S/c1-20(15,16)19-7-6-17-9-4-2-3-5-10(9)18-8-11(12,13)14/h2-5H,6-8H2,1H3

160969-03-9 Relevant articles

Preparation method of silodosin intermediate

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Paragraph 0043; 0051-0053; 0061-0063 0071-0073; 0081-0082, (2019/04/13)

The invention discloses a preparation me...

NOVEL PROCESS FOR THE SYNTHESIS OF PHENOXYETHYL DERIVATIVES

-

Page/Page column 23, (2011/09/19)

The present invention provides an improv...

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Elworthy, Todd R.,Ford, Anthony P. D. W.,Bantle, Gary W.,Morgans Jr., David J.,Ozer, Rachel S.,Palmer, Wylie S.,Repke, David B.,Romero, Magarita,Sandoval, Leticia,Sjogren, Eric B.,Talamás, Francisco X.,Vazquez, Alfredo,Wu, Helen,Arredondo, Nicolas F.,Blue Jr., David R.,DeSousa, Andrea,Gross, Lisa M.,Kava, M. Shannon,Lesnick, John D.,Vimont, Rachel L.,Williams, Timothy J.,Zhu, Quan-Ming,Pfister, Jürg R.,Clarke, David E.

, p. 2674 - 2687 (2007/10/03)

Novel arylpiperazines were identified as...

1,5,7-trisubstituted indoline compounds and salts thereof

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, (2008/06/13)

Indoline compounds represented by the fo...

160969-03-9 Process route

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol
160969-02-8

2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Reflux;
92.5%
With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;
With triethylamine; In dichloromethane; water;
With triethylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;
ethyl bromoacetate
105-36-2

ethyl bromoacetate

2-O-(2,2,2-trifluoroethyl)catechol
160968-99-0

2-O-(2,2,2-trifluoroethyl)catechol

ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate
160969-01-7

ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
Conditions Yield
With potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide;

160969-03-9 Upstream products

  • 124-63-0
    124-63-0

    methanesulfonyl chloride

  • 160969-02-8
    160969-02-8

    2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol

  • 4792-78-3
    4792-78-3

    2-(2-hydroxy-phenoxy)-ethanol

  • 120-80-9
    120-80-9

    benzene-1,2-diol

160969-03-9 Downstream products

  • 175837-07-7
    175837-07-7

    1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

  • 885340-11-4
    885340-11-4

    2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

  • 160970-54-7
    160970-54-7

    silodosin

  • 885340-13-6
    885340-13-6

    1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

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