160969-03-9
- Product Name:2-[2-(2,2,2-trifluoroethoxy)phenoxy]-Ethanol,1-methanesulfonate
- Molecular Formula:C11H13F3O5S
- Purity:99%
- Molecular Weight:314.282
Product Details;
CasNo: 160969-03-9
Molecular Formula: C11H13F3O5S
Appearance: colorless or light yellow liquid
Chinese Factory Supply 99% Pure 2-[2-(2,2,2-trifluoroethoxy)phenoxy]-Ethanol,1-methanesulfonate 160969-03-9 In Stock
- Molecular Formula:C11H13F3O5S
- Molecular Weight:314.282
- Appearance/Colour:colorless or light yellow liquid
- Vapor Pressure:0mmHg at 25°C
- Melting Point:52.0 to 56.0 °C
- Refractive Index:1.469
- Boiling Point:396.401 °C at 760 mmHg
- Flash Point:193.537 °C
- PSA:70.21000
- Density:1.362 g/cm3
- LogP:3.06350
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate(Cas 160969-03-9) Usage
Uses |
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy. |
InChI:InChI=1/C11H13F3O5S/c1-20(15,16)19-7-6-17-9-4-2-3-5-10(9)18-8-11(12,13)14/h2-5H,6-8H2,1H3
160969-03-9 Relevant articles
Preparation method of silodosin intermediate
-
Paragraph 0043; 0051-0053; 0061-0063 0071-0073; 0081-0082, (2019/04/13)
The invention discloses a preparation me...
NOVEL PROCESS FOR THE SYNTHESIS OF PHENOXYETHYL DERIVATIVES
-
Page/Page column 23, (2011/09/19)
The present invention provides an improv...
N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists
Elworthy, Todd R.,Ford, Anthony P. D. W.,Bantle, Gary W.,Morgans Jr., David J.,Ozer, Rachel S.,Palmer, Wylie S.,Repke, David B.,Romero, Magarita,Sandoval, Leticia,Sjogren, Eric B.,Talamás, Francisco X.,Vazquez, Alfredo,Wu, Helen,Arredondo, Nicolas F.,Blue Jr., David R.,DeSousa, Andrea,Gross, Lisa M.,Kava, M. Shannon,Lesnick, John D.,Vimont, Rachel L.,Williams, Timothy J.,Zhu, Quan-Ming,Pfister, Jürg R.,Clarke, David E.
, p. 2674 - 2687 (2007/10/03)
Novel arylpiperazines were identified as...
1,5,7-trisubstituted indoline compounds and salts thereof
-
, (2008/06/13)
Indoline compounds represented by the fo...
160969-03-9 Process route
-
-
124-63-0
methanesulfonyl chloride
-
-
160969-02-8
2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol
-
-
160969-03-9
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
Conditions | Yield |
---|---|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 4h;
Reflux;
|
92.5% |
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.25h;
|
|
With
triethylamine;
In
dichloromethane; water;
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
Cooling with ice;
|
-
-
105-36-2
ethyl bromoacetate
-
-
160968-99-0
2-O-(2,2,2-trifluoroethyl)catechol
-
-
160969-01-7
ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate
-
-
160969-03-9
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
Conditions | Yield |
---|---|
With
potassium carbonate;
In
ethyl acetate; N,N-dimethyl-formamide;
|
160969-03-9 Upstream products
-
methanesulfonyl chloride
-
2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol
-
2-(2-hydroxy-phenoxy)-ethanol
-
benzene-1,2-diol
160969-03-9 Downstream products
-
1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile
-
2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
-
silodosin
-
1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
Relevant Products
-
Fulvestrant
CAS:129453-61-8
-
Silodosin
CAS:160970-54-7
-
Tolterodine Tartrate
CAS:124937-52-6