What is the Norgestrel?

Norgestrel is White solid, while it's Molecular Formula is C 21 H 28 O 2 . White solid analgesic, antipyretic

What is the CAS number for Norgestrel?

The CAS number of Norgestrel is 6533-00-2.

What is Norgestrel (6533-00-2) used for?

Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component. In vivo, norgestrel administered via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.InChI:InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21?/m0/s1

What is the Norgestrel?

Norgestrel is White solid, while it's Molecular Formula is C 21 H 28 O 2 . White solid analgesic, antipyretic

What is the CAS number for Norgestrel?

The CAS number of Norgestrel is 6533-00-2.

What is Norgestrel (6533-00-2) used for?

Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component. In vivo, norgestrel administered via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.InChI:InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21?/m0/s1

Product classification

Hormones and steriods major pro

Medroxyprogesterone acetate intermediates

Progesterone intermediate

Cyproterone acetate intermediate

Deflazacort intermediate

Desogestrel intermediate

Finasteride intermediate

Steroid & Hormone Products
Major Products

Rocuronium bromide intermediate

Ubrogepant intermediate

Rimegepant intermediate

Indacaterol intermedaite

Dapagliflozin intermediate

Pharmaceutical Products

Other
Others

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6533-00-2

Product Name：Norgestrel
Molecular Formula：C₂₁H₂₈O₂
Purity：99%
Molecular Weight：312.452

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Product Details;

CasNo： 6533-00-2

Molecular Formula： C₂₁H₂₈O₂

Appearance： White solid

Reputable manufacturer supply Norgestrel 6533-00-2 in stock with high standard

Molecular Formula:C₂₁H₂₈O₂
Molecular Weight:312.452
Appearance/Colour:White solid
Vapor Pressure:0mmHg at 25°C
Melting Point:239-241 °C(lit.)
Refractive Index:1.571
Boiling Point:459.139 °C at 760 mmHg
PKA:13.09±0.40(Predicted)
Flash Point:195.446 °C
PSA：37.30000
Density:1.139 g/cm³
LogP:3.88260

Norgestrel(Cas 6533-00-2) Usage

Safety Profile	Human reproductive effects byingestion and implant: menstrual cycle changes ordisorders and female fertility index changes. Anexperimental teratogen. Experimental reproductiveeffects. Questionable carcinogen with experimentalneoplastigenic data. An o
Brand name	Ovrette (Wyeth).
General Description	Norgestrel, (17α)-(±)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, and levonorgestrel, (17α)-(-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one,have a C13 ethyl group instead of the C13 methyl but haveprogestational properties similar to those of norethindrone,with decreased androgenic effects. The ethyl group apparentlyprovides unfavorable steric interactions with the ARthat reduce the affinity compared with that with the PRs.Norgestrel is a racemic mixture, while levonorgestrel is thesingle active levorotatory enantiomer. Norgestrel is usedonly in oral contraceptives. Levonorgestrel is used in bothoral combination birth control products and polymeric implantsthat provide contraception for up to 5 years.

InChI:InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21?/m0/s1

6533-00-2 Relevant articles

Preparation method of levonorgestrel

-

Paragraph 0025; 0027-0028; 0030-0031; 0033, (2020/09/20)

The invention discloses a preparation me...

Total-synthesis of (-)-norgestrel

Baier,Durner,Quinkert

, p. 1054 - 1068 (2007/10/02)

Synthesis of 13-alkyl-gon-4-ones

-

, (2008/06/13)

The preparation of 13-methylgon-4-enes a...

Steroid total synthesis. IV.(+)-13 -ethyl-17 -ethynyl-17 -hydroxy-gon-4-en-3-one.

Rosenberger,Fraher,Saucy

, p. 2857 - 2870 (2007/10/06)

6533-00-2 Process route

: 2-Ethyl-3-vinyl-cyclopentanone

: 797-63-7,797-64-8,17092-09-0,6533-00-2
norgestrel

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 80 percent NaH, Et₃N / 1,2-dimethoxy-ethane; paraffin / 1.) 3.5 h, reflux; 2.) 40 min 2: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation 3: 99 percent / LiAlH₄ / diethyl ether 4: 62 percent / K, aniline, NH₃ / tetrahydrofuran / 1 h 5: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene 6: 0.16 g / LDA / tetrahydrofuran With pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; ammonia; oxalic acid; aluminum isopropoxide; sodium hydride; triethylamine; aniline; butanone; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; paraffin; benzene;
Multi-step reaction with 7 steps 1: 86 percent / TsOHH₂O / 14 h / Heating 2: 1.) 1.3 M MeLi; 2.) 10 percent H₂SO₄ / 1.) Et₂O, 0.5 h; -20 deg C, 3h; 2.) Et₂O, 14 h, RT 3: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation 4: 99 percent / LiAlH₄ / diethyl ether 5: 62 percent / K, aniline, NH₃ / tetrahydrofuran / 1 h 6: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene 7: 0.16 g / LDA / tetrahydrofuran With* pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; sulfuric acid; ammonia; methyllithium; oxalic acid; aluminum isopropoxide; toluene-4-sulfonic acid; aniline; butanone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; benzene;
Multi-step reaction with 6 steps 1: 1.) NaH, 2.) H₂SO₄ / 1.) DME, paraffin oil; Et₂O; 2.) MeOH 2: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation 3: 99 percent / LiAlH₄ / diethyl ether 4: 62 percent / K, aniline, NH₃ / tetrahydrofuran / 1 h 5: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene 6: 0.16 g / LDA / tetrahydrofuran With pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; sulfuric acid; ammonia; oxalic acid; aluminum isopropoxide; sodium hydride; aniline; butanone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; benzene;

: 23855-42-7,35442-18-3,35442-19-4
(5R,8R,9S,10R,13S,14S)-13-Ethyl-5-hydroxy-3-methyl-tetradecahydro-4-oxa-cyclopenta[a]phenanthren-17-one

: 797-63-7,797-64-8,17092-09-0,6533-00-2
norgestrel

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NBS / acetone 2: (i) liq. NH₃ (ii) /BRN= 4147360/, benzene, Et₂O With N-Bromosuccinimide; In acetone;
Multi-step reaction with 3 steps 1: CrO₃, H₂SO₄ / acetone 2: TsOH / benzene 3: (i) liq. NH₃ (ii) /BRN= 4147360/, benzene, Et₂O With chromium(VI) oxide; sulfuric acid; toluene-4-sulfonic acid; In acetone; benzene;