154229-18-2
- Product Name：Abiraterone acetate
- Molecular Formula：C26H33NO2
- Purity：99%
- Molecular Weight：391.554
Product Details;
CasNo： 154229-18-2
Molecular Formula： C26H33NO2
Quality products make an important contribution to long-term revenue and profitability. Cost-effective and customizable Abiraterone acetate 154229-18-2 for sale
1.What is the 17-(3-pyridyl)-5,16-androstadien-3beta-acetate ?
A novel steroidal inhibitor of human Cytochrome P450(17a-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
-
-
115375-60-5
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
-
-
89878-14-8
3-Diethylboranylpyridine
-
-
154229-18-2
abiraterone acetate
| Conditions | Yield |
|---|---|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran;
at 65 ℃;
for 4h;
Reflux;
|
95% |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
for 1h;
Reflux;
|
95% |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 60 ℃;
for 1h;
|
94% |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
for 18h;
Inert atmosphere;
Reflux;
|
90% |
|
With
bis(triphenylphosphine)palladium(II)-chloride; sodium carbonate;
In
tetrahydrofuran;
at 80 ℃;
for 1h;
|
84% |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 60 ℃;
for 23h;
Inert atmosphere;
|
77% |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
for 1h;
Inert atmosphere;
Reflux;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
2-methyltetrahydrofuran; water;
at 20 - 80 ℃;
for 2.15h;
Inert atmosphere;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
at 66 ℃;
for 3.5h;
|
15.68 g |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
at 25 - 80 ℃;
for 6h;
Inert atmosphere;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 1.5h;
Temperature;
Concentration;
Reflux;
Large scale;
|
65 kg |
|
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate; 3-Diethylboranylpyridine;
With
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
With
sodium carbonate;
In
tetrahydrofuran; water;
Inert atmosphere;
Reflux;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
Reflux;
Inert atmosphere;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
for 2h;
Inert atmosphere;
Reflux;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran; water;
for 2h;
Reflux;
|
496.5 g |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
tetrahydrofuran;
at 80 ℃;
|
-
-
75-36-5
acetyl chloride
-
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154229-19-3
abiraterone
-
-
154229-18-2
abiraterone acetate
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine;
In
diethyl ether;
at 20 ℃;
for 4h;
|
85.1% |
|
With
2-(Dimethylamino)pyridine; triethylamine;
In
diethyl ether; ethanol; hexane; water;
|
84% |
|
With
triethylamine;
In
ethyl acetate;
at 5 - 20 ℃;
for 2h;
|
83% |
|
With
N-ethyl-N,N-diisopropylamine;
In
diethyl ether;
at 20 ℃;
for 3h;
|
83.18% |
|
With
triethylamine;
In
diethyl ether;
at 20 ℃;
for 3h;
Concentration;
|
81.8% |
|
With
pyridine;
In
dichloromethane;
|
70% |
|
With
2-(Dimethylamino)pyridine;
In
diethyl ether;
|
|
|
With
dmap; triethylamine;
In
dichloromethane;
at 20 - 30 ℃;
for 2h;
|
0.745 g |
2.What is the CAS number for 17-(3-pyridyl)-5,16-androstadien-3beta-acetate ?
The CAS number of 17-(3-pyridyl)-5,16-androstadien-3beta-acetate is 154229-18-2.
More information of 17-(3-pyridyl)-5,16-androstadien-3beta-acetate 154229-18-2 are:
|
CAS Number |
154229-18-2 |
|
Density |
1.14 g/cm3 |
|
Melting Point |
127-130°C |
|
Boiling Point |
506.709 °C at 760 mmHg |
|
Flash Point |
260.249 °C |
|
Vapor Pressure |
2.17E-10mmHg at 25°C |
|
Refractive Index |
1.583 |
|
HS CODE |
2937290000 |
|
PSA |
39.19000 |
|
LogP |
5.96940 |
|
Pka |
5.31±0.12(Predicted) |
3.What are another words for 17-(3-pyridyl)-5,16-androstadien-3beta-acetate ?
Synonyms for 17-(3-pyridyl)-5,16-androstadien-3beta-acetate 154229-18-2:Abirateroneacetate;CB 7630;(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate;Abiraterone acetate;
4.What is the molecular formula of 17-(3-pyridyl)-5,16-androstadien-3beta-acetate?
The chemical formula of 17-(3-pyridyl)-5,16-androstadien-3beta-acetate is C26H33NO2 which containing 26 Carbon atoms,33 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of 17-(3-pyridyl)-5,16-androstadien-3beta-acetate is 391.554.
5.What is 17-(3-pyridyl)-5,16-androstadien-3beta-acetate (154229-18-2) used for?
In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).
InChI:InChI=1/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21?,23?,24?,25-,26+/m0/s1
Relevant articles related to 17-(3-pyridyl)-5,16-androstadien-3beta-acetate:
|
Article |
Source |
|
Synthesis of the anti-prostate cancer drug abiraterone acetate |
Ma, Siyue,Li, Jianheng,Tang, Huayang,Xu, Feng , p. 461 - 469 (2018) |
|
Slow-, tight-binding inhibition of CYP17A1 by abiraterone redefines its kinetic selectivity and dosing regimen |
Cheong, Eleanor Jing Yi,Nair, Pramod C.,Neo, Rebecca Wan Yi,Tu, Ho Thanh,Lin, Fu,Chiong, Edmund,Esuvaranathan, Kesavan,Fan, Hao,Szmulewitz, Russell Z.,Peer, Cody J.,Figg, William D.,Chai, Christina Li Lin,Miners, John O.,Chan, Eric Chun Yong supporting information, p. 438 - 451 (2020/09/04) |
6.Buy 17-(3-pyridyl)-5,16-androstadien-3beta-acetate with the best price .
Golden Pharma Co., Limited is a quality supplier of 17-(3-pyridyl)-5,16-androstadien-3beta-acetate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 17-(3-pyridyl)-5,16-androstadien-3beta-acetate 154229-18-2.
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