1375541-21-1
- Product Name：Ubrogepant Acid Intermediate
- Molecular Formula：
- Purity：99%
- Molecular Weight：281.271
Product Details;
CasNo： 1375541-21-1
Buy Quality Sale Ubrogepant Acid Intermediate 1375541-21-1 In Stock
- Molecular Formula:C15H11N3O3
- Molecular Weight:281.271
Ubrogepant Intermediate(Cas 1375541-21-1) Usage
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Uses |
This is ubrogepant's intermediate, used as chemical references/standards. |
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Consumer Uses |
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. |
1375541-21-1 Relevant articles
Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles
Gao, Min,Hu, Lin,Li, Xuemin,Li, Yongyi
supporting information, p. 875 - 880 (2022/02/05)
A general phase-transfer-catalyzed asymm...
Calcitonin gene-related peptide (CGRP) receptor antagonist treatment of migraine
Gras
, p. 869 - 879 (2020/01/21)
Migraine is ranked as the sixth cause of...
Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant
Yasuda, Nobuyoshi,Cleator, Ed,Kosjek, Birgit,Yin, Jianguo,Xiang, Bangping,Chen, Frank,Kuo, Shen-Chun,Belyk, Kevin,Mullens, Peter R.,Goodyear, Adrian,Edwards, John S.,Bishop, Brian,Ceglia, Scott,Belardi, Justin,Tan, Lushi,Song, Zhiguo J.,Dimichele, Lisa,Reamer, Robert,Cabirol, Fabien L.,Tang, Weng Lin,Liu, Guiquan
, p. 1851 - 1858 (2017/11/24)
The development of a scalable asymmetric...
Process for Making CGRP Receptor Antagonists
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Paragraph 0251; 0252, (2016/06/01)
The invention encompasses a novel proces...
1375541-21-1 Process route
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![(S)-1‘-(tert-butyl)-2’-oxo-1‘,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid](/upload/2023/9/e074e812-035d-4314-b98f-0c19371cfa8b.png)
- 1455358-16-3
(S)-1‘-(tert-butyl)-2’-oxo-1‘,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid
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![(S)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxylic acid](/upload/2023/9/d9bbba24-45d2-4047-be29-69f9b53d9b9c.png)
- 1375541-21-1
(S)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxylic acid
| Conditions | Yield |
|---|---|
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(S)-1‘-(tert-butyl)-2’-oxo-1‘,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid; With hydrogenchloride; In water; at 94 ℃; for 48h;
With sodium hydroxide; In water; pH=2.6;
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94% |
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With hydrogenchloride; In water; at 94 ℃; for 48h;
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94% |
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With hydrogenchloride; In water; at 94 ℃; for 48h;
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94% |
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With hydrogenchloride; In water; at 94 ℃;
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![methyl (6S)-2'-oxo-1',2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate](/upload/2023/9/b10a9ad6-aaa9-4a07-aaa5-e00f651471b4.png)
- 1375541-24-4
methyl (6S)-2'-oxo-1',2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate
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- 1375541-21-1
(S)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxylic acid
| Conditions | Yield |
|---|---|
|
methyl (6S)-2'-oxo-1',2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate; With sodium hydroxide; In methanol; for 1h; Reflux;
With hydrogenchloride; In methanol; water; at 23 ℃; pH=~ 6;
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|
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methyl (6S)-2'-oxo-1',2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate; With sodium hydroxide; In methanol; water; for 1h; Reflux;
With hydrogenchloride; methanol; water; at 23 ℃; pH=Ca. 6;
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With water; sodium hydroxide; In methanol; for 1h; Reflux;
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With water; sodium hydroxide; In methanol; Reflux;
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1375541-21-1 Upstream products
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89-00-9
Pyridine-2,3-dicarboxylic acid
-
1059186-43-4
(6S)-3-amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
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1189570-15-7
(6S)-3-iodo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
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1375541-24-4
methyl (6S)-2'-oxo-1',2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate
1375541-21-1 Downstream products
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1374248-77-7
(6S)-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
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1374248-79-9
(6S)-N-[(3S,5S,6R)-5-(2-Fluoro-3-methylphenyl)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
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1374248-80-2
(S)-N-((3S,5S,6R)-6-methyl-2-oxo-5-(o-tolyl)-1-(2,2,2-trifluoroethyl)piperidin-3-yl)-2’-oxo-l‘,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxamide
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1374248-77-7
(6S)-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide
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