452339-73-0
- Product Name：(5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
- Molecular Formula：C13H15NO4
- Purity：99%
- Molecular Weight：249.266
Product Details;
CasNo： 452339-73-0
Molecular Formula： C13H15NO4
Factory sells (5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one 452339-73-0 with sufficient production capacity
- Molecular Formula:C13H15NO4
- Molecular Weight:249.266
- Melting Point:160 - 163°C
- Boiling Point:489.6±45.0 °C(Predicted)
- PKA:12.29±0.40(Predicted)
- PSA：60.28000
- Density:1.223±0.06 g/cm3(Predicted)
- LogP:1.75260
452339-73-0 Relevant articles
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Paragraph 0014-0015, (2017/08/31)
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-
Paragraph 0133; 0134, (2015/09/23)
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-
Page/Page column 54, (2008/06/13)
The present invention provides a compoun...
452339-73-0 Process route
-
-
452339-72-9
tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate
-
-
452339-73-0
(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
| Conditions | Yield |
|---|---|
|
With
heteropoly acid;
In
ethyl acetate;
at 10 - 15 ℃;
Solvent;
Temperature;
|
90.2% |
|
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
|
70% |
|
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 10 - 20 ℃;
for 1h;
|
70% |
|
tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate;
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 0 - 21 ℃;
for 2h;
With
hydrogenchloride;
In
DMF (N,N-dimethyl-formamide); water;
at 0 ℃;
|
|
|
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 0 - 21 ℃;
for 2h;
|
|
|
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 0 - 21 ℃;
for 2h;
|
|
|
tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 21 ℃;
for 2h;
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
|
|
|
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
|
700 mg |
-
-
208925-08-0
(2R)-hydroxy-2-(2,2-dimethyl-4H-1,3-benzodioxine-6-yl)-ethylamine
-
-
530-62-1
1,1'-carbonyldiimidazole
-
-
452339-73-0
(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
chloroform;
at 20 ℃;
|
51% |
452339-73-0 Upstream products
-
452339-72-9
tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate
-
102293-80-1
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
-
452339-71-8
tert-butyl 2-(2,2-dimethyl-4H-1,3-benzodioxane-6-yl)-2-carbonylethylcarbamate
-
452339-70-7
di-(tert-butyl) 2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyliminodicarbonate
452339-73-0 Downstream products
-
590410-68-7
(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-[6-(4-phenylbutoxy)hexyl]-1,3-oxazolidin-2-one
-
135271-47-5
(R)-(-)-salmeterol
-
590410-69-8
(R)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-(6-(4-phenylbutoxy)hexylamino)ethanol
-
671777-40-5
(5R)-5-(2, 2-DIMETHVL-4H-1, 3-BENZODIOXIN-6-VL)-3-F6-R4-(3-IODOPHENVL) BUTOXVLHEXVL-1, 3-oxazolidin-2-one
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