951753-87-0
- Product Name：5-isothiocyanato-3-(trifluoromethyl)picolinonitrile
- Molecular Formula：C8H2F3N3S
- Purity：99%
- Molecular Weight：229.185
Product Details;
CasNo： 951753-87-0
Molecular Formula： C8H2F3N3S
Manufacturer supply 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile 951753-87-0 with sufficient stock and high standard
- Molecular Formula:C8H2F3N3S
- Molecular Weight:229.185
- Boiling Point:367.7±42.0 °C(Predicted)
- PKA:-5.54±0.21(Predicted)
- PSA：81.13000
- Density:1.41±0.1 g/cm3(Predicted)
- LogP:2.70638
951753-87-0 Relevant articles
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer
Zhang, Zhuming,Connolly, Peter J.,Trabalón Escolar, Luis,Rocaboy, Christian,Pande, Vineet,Meerpoel, Lieven,Lim, Heng-Keang,Branch, Jonathan R.,Ondrus, Janine,Hickson, Ian,Bush, Tammy L.,Bischoff, James R.,Bignan, Gilles
supporting information, p. 1245 - 1252 (2021/07/26)
Androgen receptor (AR) transcriptional r...
The invention relates to a synthetic method of. Intermediate and synthetic method
-
Paragraph 0091-0096, (2021/11/27)
The invention belongs to the technical f...
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
Wang, Ao,Wang, Yawan,Meng, Xin,Yang, Yushe
, (2021/01/07)
Prostate cancer (PC) is the most common ...
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)
Zhang, Zhuming,Connolly, Peter J.,Lim, Heng Keang,Pande, Vineet,Meerpoel, Lieven,Teleha, Christopher,Branch, Jonathan R.,Ondrus, Janine,Hickson, Ian,Bush, Tammy,Luistro, Leopoldo,Packman, Kathryn,Bischoff, James R.,Ibrahim, Salam,Parrett, Christopher,Chong, Yolanda,Gottardis, Marco M.,Bignan, Gilles
supporting information, p. 909 - 924 (2021/02/06)
Persistent androgen receptor (AR) activa...
951753-87-0 Process route
-
-
573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
-
-
463-71-8
thiophosgene
-
-
951753-87-0
5-isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
In
chloroform; N,N-dimethyl acetamide; water;
at 20 ℃;
for 0.333333h;
|
100% |
|
In
acetonitrile;
at 20 - 30 ℃;
Inert atmosphere;
|
100% |
|
In
chloroform; N,N-dimethyl acetamide; water;
at 20 ℃;
for 0.5h;
|
100% |
|
In
dichloromethane; water;
at 20 ℃;
for 16h;
|
97% |
|
In
water;
for 2h;
|
95% |
|
In
water;
at 25 ℃;
for 2h;
Temperature;
|
95% |
|
In
acetone;
at 20 ℃;
|
86% |
|
In
chloroform; water;
at 20 ℃;
for 12h;
|
77% |
|
In
toluene;
at 110 ℃;
for 12h;
|
77.2% |
|
In
water;
at 25 ℃;
for 4h;
Temperature;
Time;
|
73.9% |
|
In
water;
at 20 - 25 ℃;
for 4h;
|
44.09% |
|
In
water;
for 2.5h;
|
0.7 g |
|
In
dichloromethane; water;
at 20 - 30 ℃;
for 4h;
Temperature;
Inert atmosphere;
|
20 g |
|
In
tetrahydrofuran; water;
at 10 ℃;
for 5h;
|
|
|
In
chloroform; N,N-dimethyl acetamide; water;
at 20 ℃;
for 0.5h;
|
|
|
In
water;
at 15 - 30 ℃;
for 5h;
|
52 g |
-
-
573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
-
-
2,2‐difluoro‐2‐(triphenylphosphonio)acetate
-
-
951753-87-0
5-isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
With
sulfur;
In
chloroform;
at 60 ℃;
|
84% |
951753-87-0 Upstream products
-
573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
-
463-71-8
thiophosgene
-
3796-23-4
3-(trifluoromethyl)pyridine
-
22253-72-1
3-(trifluoromethyl)pyridine-N-oxide
951753-87-0 Downstream products
-
1332389-99-7
methyl 4-(4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)phenyl)butanoate
-
1332389-96-4
tert-butyl 4-(4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)phenyl)piperazine-1-carboxylate
-
956104-39-5
5-(8-oxo-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7yl)-3-trifluoromethylpyridine-2-carbonitrile
-
956104-40-8
ARN-509
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