19608-29-8

  • Product Name:Clascoterone
  • Molecular Formula:C24H34O5
  • Purity:99%
  • Molecular Weight:402.531
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Product Details;

CasNo: 19608-29-8

Molecular Formula: C24H34O5

Quality products make an important contribution to long-term revenue and profitability. High Quality Chinese Manufacturer supply 19608-29-8 Clascoterone

1.What is the 17Alpha-propionate ?

Clascoterone is being developed as a topical cream by Cassiopea for androgen-?dependent skin disorders.

cortexolone 17α,21-dipropionate
19608-30-1

cortexolone 17α,21-dipropionate

CB-03-01
19608-29-8

CB-03-01

Conditions
Conditions Yield
With butan-1-ol; Candida cylindracea lipase; In toluene; at 30 ℃; for 24h; Product distribution / selectivity; Enzymatic reaction;
99%
Candida cylandracea lipase; In toluene; butan-1-ol; at 30 ℃; for 24h;
96%

2.What is the CAS number for 17Alpha-propionate ?

The CAS number of 17Alpha-propionate is 19608-29-8.

More information of 17Alpha-propionate 19608-29-8 are:

CAS Number

19608-29-8

Density

1.193 g/cm3

Boiling Point

538.898 °C at 760 mmHg

Flash Point

179.292 °C

PSA

80.67000

LogP

3.77170

Pka

12.98±0.10(Predicted)

3.What are another words for 17Alpha-propionate ?

Synonyms for 17Alpha-propionate 19608-29-8:17alpha-propionate;21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione;CB-03-01;Cortexolone 17-alpha-propionate

4.What is the molecular formula of 17Alpha-propionate?

The chemical formula of  17Alpha-propionate is C24H34O5 which containing 24 Carbon atoms,34 Hydrogen atoms and 5 Oxygen atoms,and the molecular weight of  17Alpha-propionate is 402.531.

5.What is 17Alpha-propionate (19608-29-8) used for?

Clascoterone (Winlevi?) is an androgen receptor inhibitor being developed as a topical cream and solution by Cassiopea (a spin-out company of Cosmo Pharmaceuticals) for the treatment of androgen-dependent skin disorders, including androgenetic alopecia and acne vulgaris. Although the exact mechanism of action of clascoterone for the topical treatment of acne vulgaris is unknown, the drug is believed to compete with the androgen dihydrotestosterone for binding to androgen receptors in the sebaceous gland and hair follicles to attenuate signalling necessary for acne pathogenesis. In August 2020, clascoterone cream 1% received its first approval in the USA for the topical treatment of acne vulgaris in patients 12 years of age or older. Clinical studies of a different formulation of clascoterone (a solution containing a higher concentration of the drug) for the treatment of androgenetic alopecia are underway in Germany and the USA. This article summarizes the milestones in the development of clascoterone leading to this first approval for the topical treatment of acne vulgaris.

Relevant articles related to 17Alpha-propionate:

Article

Source

Lipase-catalyzed preparation of corticosteroid 17α-esters endowed with antiandrogenic activity

Ferraboschi, Patrizia,Mieri, Maria De,Ragonesi, Laura

, p. 4610 - 4612 (2008/09/21)

6.Buy 17Alpha-propionate with the best price .

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