398489-26-4
- Product Name：1-Boc-3-azetidinone
- Molecular Formula：C8H13NO3
- Purity：99%
- Molecular Weight：171.196
Product Details;
CasNo： 398489-26-4
Molecular Formula： C8H13NO3
Factory Supply Industrial Grade 1-Boc-3-azetidinone 398489-26-4 with Best Price
- Molecular Formula:C8H13NO3
- Molecular Weight:171.196
- Vapor Pressure:0.0369mmHg at 25°C
- Melting Point:49-52 °C
- Boiling Point:251.3 °C at 760 mmHg
- PKA:-1.99±0.20(Predicted)
- Flash Point:105.8 °C
- PSA：46.61000
- Density:1.174 g/cm3
- LogP:0.74410
tert-Butyl 3-oxoazetidine-1-carboxylate(Cas 398489-26-4) Usage
|
General Description |
tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation. |
InChI:InChI=1/C6H14N2.2ClH/c1-8-4-2-3-6(7)5-8;;/h6H,2-5,7H2,1H3;2*1H
398489-26-4 Relevant articles
Method for preparing aldehyde or ketone by oxidizing reaction alcohol oxide
-
Paragraph 0025-0036, (2021/11/03)
The invention relates to a method for pr...
PROCESSES OF PREPARING A JAK1 INHIBITOR
-
, (2021/12/17)
The present application provides process...
3-nitrile methylene azetidine-1-tert-butyl carbonate preparation method
-
Page/Page column 15; 17-19, (2020/02/06)
The invention discloses a 3-nitrile meth...
Preparation method of medicine intermediate 1 -tert-butoxycarbonyl -3 -azetidinone (by machine translation)
-
Paragraph 0081-0086, (2020/07/15)
The invention relates to the technical f...
398489-26-4 Process route
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-
141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate
-
-
398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate
| Conditions | Yield |
|---|---|
|
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
acetonitrile;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
Molecular sieve;
|
99% |
|
With
1-methyl-1H-imidazole; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 4,4'-Dimethoxy-2,2'-bipyridin; 9-azabicyclo[3.3.1]nonane N-oxyl; oxygen;
In
acetonitrile;
at 20 ℃;
for 0.5h;
Time;
|
98% |
|
With
oxygen; nitric acid; 3-carboxy proxyl;
In
ethyl acetate;
at 50 ℃;
for 8h;
Reagent/catalyst;
Temperature;
Solvent;
|
98.11% |
|
With
pyridine-SO3 complex; triethylamine;
In
dimethyl sulfoxide;
at 10 - 20 ℃;
Inert atmosphere;
|
95% |
|
With
sulfur trioxide pyridine complex; triethylamine;
In
dimethyl sulfoxide;
at 10 ℃;
for 20h;
Inert atmosphere;
|
95% |
|
With
sulfur trioxide pyridine complex; triethylamine;
In
dimethyl sulfoxide;
at 10 - 20 ℃;
Inert atmosphere;
Cooling with ice;
|
95% |
|
With
1-methyl-1H-imidazole; copper(l) iodide; 9-azabicyclo[3.3.1]nonane N-oxyl; oxygen;
In
1-methyl-pyrrolidin-2-one;
at 60 ℃;
for 1h;
|
92% |
|
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; dihydrogen peroxide;
In
dichloromethane; water;
at 5 ℃;
for 0.00833333h;
Reagent/catalyst;
Temperature;
Solvent;
|
92.1% |
|
tert-butyl 3-hydroxyazetidine-1-carboxylate;
With
oxalyl dichloride;
dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
|
91.1% |
|
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 15h;
|
90% |
|
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 15h;
|
90% |
|
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 15h;
|
90% |
|
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 15h;
|
90% |
|
With
oxalyl dichloride; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at -78 - 20 ℃;
for 15h;
|
90% |
|
With
oxalyl dichloride; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at -78 - 20 ℃;
|
81% |
|
With
pyridine-SO3 complex; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at 10 - 20 ℃;
for 1.5h;
|
81% |
|
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
acetonitrile;
at 0 - 20 ℃;
Molecular sieve;
|
73% |
|
With
DMP;
In
dichloromethane;
at 20 ℃;
|
55% |
|
With
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at 0 ℃;
for 3h;
|
52% |
|
With
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at 0 ℃;
|
52% |
|
With
sodium hypochlorite; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; sodium hydrogencarbonate; potassium bromide;
In
water; ethyl acetate;
at 0 - 5 ℃;
|
|
|
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 1h;
|
|
|
With
pyridine-SO3 complex; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at 0 - 20 ℃;
for 18h;
|
|
|
With
sulfur trioxide-pyridine complex; triethylamine;
In
dimethyl sulfoxide;
at 20 - 50 ℃;
for 2.5h;
|
|
|
With
triethylamine;
sulfur trioxide pyridine complex;
In
chloroform; dimethyl sulfoxide;
at 20 ℃;
for 4h;
|
|
|
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide;
In
water; ethyl acetate;
at 0 - 5 ℃;
|
|
|
With
9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; acetic acid; sodium nitrite;
at 20 ℃;
for 3h;
under 760.051 Torr;
Reagent/catalyst;
Solvent;
|
98 %Spectr. |
|
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide;
In
water; ethyl acetate;
at 0 - 5 ℃;
|
|
|
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 - 35 ℃;
|
650 mg |
|
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 - 35 ℃;
|
650 mg |
|
With
pyridine-SO3 complex; N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
for 2h;
|
|
|
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide;
In
water; ethyl acetate;
at 0 - 5 ℃;
|
|
|
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; tert-butylamine; potassium bromide;
In
ethyl acetate;
at 0 ℃;
for 2.5h;
pH=9.8;
pH-value;
Temperature;
|
-
-
1-tert-butoxycarbonyl-3,3-dimethoxyazetidine
-
-
398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate
| Conditions | Yield |
|---|---|
|
With
citric acid;
In
water; ethyl acetate;
at 20 - 40 ℃;
|
85.4% |
398489-26-4 Upstream products
-
141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate
-
24424-99-5
di-tert-butyl dicarbonate
-
20599-01-3
2,2-bis(bromomethyl)-1,3-dioxolane
-
4248-19-5
tert-butyl carbazate
398489-26-4 Downstream products
-
958297-39-7
3-phenylazetidin-3-ol trifluoroacetate
-
958297-44-4
tert-butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate
-
792970-55-9
tert-butyl 3-(dimethylamino)azetidine-1-carboxylate
-
864248-52-2
tert-butyl 3-(4-benzylpiperazin-1-yl)azetidine-1-carboxylate
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