594839-88-0
- Product Name：Tafamidis
- Molecular Formula：C14H7Cl2NO3
- Purity：99%
- Molecular Weight：308.12
Product Details;
CasNo： 594839-88-0
Molecular Formula： C14H7Cl2NO3
High Quality Chinese Manufacturer supply 594839-88-0 Tafamidis
- Molecular Formula:C14H7Cl2NO3
- Molecular Weight:308.12
- Boiling Point:486.7±40.0 °C(Predicted)
- PKA:3.49±0.30(Predicted)
- PSA：63.33000
- Density:1.530
- LogP:4.49980
594839-88-0 Relevant articles
A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition
Sim?es, Carlos J.V.,Almeida, Zaida L.,Costa, Dora,Jesus, Catarina S.H.,Cardoso, Ana L.,Almeida, Maria R.,Saraiva, Maria J.,Pinho e Melo, Teresa M.V. D.,Brito, Rui M.M.
, p. 823 - 840 (2016)
The design and synthesis of a novel bis-...
A new synthesis of tafamidis via zinc-MsOH mediated reductive cyclisation strategy
Karumanchi, Kishore,Natarajan, Senthil Kumar,Gadde, Sunil,Vanchanagiri, Krishna,Moturu, Krishnamurthy V R
, (2021)
A practical zinc-MsOH mediated intra-mol...
IMPROVED PROCESS FOR THE PREPARATION OF 2-(3,5-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND POLYMORPHS THEREOF
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Page/Page column 18, (2021/01/23)
The present invention relates to process...
PROCESS FOR THE PREPARATION OF TRANSTHYRETIN DISSOCIATION INHIBITOR
-
Page/Page column 11, (2021/02/05)
The present invention relates to Tafamid...
EFFICIENT PROCESS FOR MAKING 6-CARBOXY BENZOXAZOLE DERIVATIVES
-
Page/Page column 43, (2021/06/26)
The present invention is directed to an ...
IMPROVED PROCESSES FOR THE PREPARATION OF TAFAMIDIS AND ITS MEGLUMINE SALT
-
Paragraph 19; 20, (2021/08/06)
The present invention relates to improve...
594839-88-0 Process route
-
-
2-(3,5-dichlorophenyl)-2-methoxy-1,3-dioxolane
-
-
2374-03-0
4-aminosalicylic acid
-
-
594839-88-0
2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
trifluoroacetic acid;
In
isopropyl alcohol;
at 85 ℃;
for 12h;
|
86.7% |
-
![4-[(3,5-dichlorobenzoyl)amino]-3-hydroxybenzoic acid](/upload/2026/9/ece484d8-10e3-4a87-8d9a-b451bfd9ddd5.png)
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4-[(3,5-dichlorobenzoyl)amino]-3-hydroxybenzoic acid
-
-
594839-88-0
2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
toluene-4-sulfonic acid;
In
xylene;
Heating;
|
|
|
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / Reflux
1.2: 25 °C
2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C
With
lithium hydroxide monohydrate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water;
|
|
|
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / Reflux
1.2: 0.5 h / 25 °C
2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 6 h / 20 °C
With
lithium hydroxide monohydrate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water;
|
|
|
With
triethylamine;
In
tetrahydrofuran; water;
at 20 - 25 ℃;
for 1h;
|
|
|
With
methanesulfonic acid;
In
1-methyl-pyrrolidin-2-one; toluene;
at 117 - 119 ℃;
for 15h;
|
|
|
4-[(3,5-dichlorobenzoyl)amino]-3-hydroxybenzoic acid;
With
triethylamine;
In
toluene;
at 25 - 30 ℃;
for 1h;
With
methanesulfonic acid;
In
toluene;
at 110 - 115 ℃;
for 14h;
|
|
|
4-[(3,5-dichlorobenzoyl)amino]-3-hydroxybenzoic acid;
With
triethylamine;
In
tetrahydrofuran; water;
at 20 - 25 ℃;
for 1h;
With
methanesulfonic acid;
In
toluene;
at 107 ℃;
for 15h;
|
594839-88-0 Upstream products
-
154235-77-5
1,3-benzoxazole-6-carboxylic Acid
-
1334429-35-4
4-(6-benzoxazoyl)morpholine
-
2374-03-0
4-aminosalicylic acid
-
2905-62-6
3,5-dichlorobenzoyl chloride
594839-88-0 Downstream products
-
951395-08-7
1-deoxy-1-methylamino-D-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate
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