22766-68-3
- Product Name：1-Azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester
- Molecular Formula：C10H17NO2
- Purity：99%
- Molecular Weight：183.25
Product Details;
CasNo： 22766-68-3
Molecular Formula： C10H17NO2
Quality Factory Sells Top Purity 99% 1-Azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester 22766-68-3 with Safe Delivery
- Molecular Formula:C10H17NO2
- Molecular Weight:183.25
- Boiling Point:233.4±40.0 °C(Predicted)
- PKA:9.44±0.12(Predicted)
- PSA：29.54000
- Density:1.09±0.1 g/cm3(Predicted)
- LogP:0.97330
22766-68-3 Relevant articles
A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide
Espadinha, Margarida,Louren?o, Nuno M. T.,Sobral, Luis,Antunes, Rafael,Santos, Maria M. M.
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A more sustainable process for the synth...
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-
Paragraph 0028; 0029; 0038; 0039; 0044; 0045, (2021/04/14)
The invention relates to a preparation m...
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-
Paragraph 0054; 0058-0060, (2020/08/18)
The invention discloses a method for syn...
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-
Page/Page column 13, (2018/05/27)
The present invention discloses processe...
22766-68-3 Process route
-
-
869112-14-1
1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester
-
![azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester](/upload/2026/9/b84dfb3f-1cb9-4e10-8083-72991f5bb732.png)
-
22766-68-3
azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
|
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -50 - 20 ℃;
for 16.4167h;
Solvent;
Inert atmosphere;
|
99.4% |
|
With
diisopropylamine;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -50 - 20 ℃;
for 16.4167h;
|
95.7% |
|
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -50 - 20 ℃;
for 16.25h;
Inert atmosphere;
|
95.7% |
|
1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -50 - 20 ℃;
With
water; potassium carbonate;
In
tetrahydrofuran; n-heptane; ethylbenzene;
|
95.7% |
|
With
n-butyllithium; diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 - 25 ℃;
for 21h;
|
90% |
|
With
lithium hexamethyldisilazane;
In
dichloromethane;
at 44 - 45 ℃;
Industrial scale;
|
80% |
|
With
potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
at 40 ℃;
Inert atmosphere;
|
60.11% |
|
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -50 - 20 ℃;
for 16h;
Inert atmosphere;
|
3.02 g |
|
With
potassium hexamethylsilazane;
In
toluene;
at -20 ℃;
for 4h;
Temperature;
Reagent/catalyst;
|
-
-
ethyl 1-(2-chloroethyl)piperidine-4-carboxylate hydrochloride
-
-
22766-68-3
azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
|
ethyl 1-(2-chloroethyl)piperidine-4-carboxylate hydrochloride;
With
potassium carbonate;
In
water; toluene;
for 0.166667h;
With
potassium hexamethylsilazane;
In
toluene;
at 40 ℃;
for 2h;
|
22766-68-3 Upstream products
-
869112-14-1
1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester
-
1276088-72-2
ethyl-4-(2-chloroethyl)-piperidine-4-carboxylate hydrochloride
-
142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate
-
1126-09-6
4-carbethoxypiperidine
22766-68-3 Downstream products
-
26608-58-2
4-hydroxymethylquinuclidine
-
45651-41-0
4-Methyl-chinuclidin
-
461648-39-5
α,α-diphenyl-1-azabicyclo[2.2.2]octane-4-methanol
-
55022-91-8
quinuclidine-4-carbaldehyde
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