6559-91-7
- Product Name：4'-Demethylepipodophyllotoxin
- Molecular Formula：C21H20O8
- Purity：99%
- Molecular Weight：400.385
Product Details;
CasNo： 6559-91-7
Molecular Formula： C21H20O8
Appearance： White crystalline powder
Buy High Quality 4'-Demethylepipodophyllotoxin 6559-91-7 Efficient Shipping
- Molecular Formula:C21H20O8
- Molecular Weight:400.385
- Appearance/Colour:White crystalline powder
- Melting Point:246-248 °C
- Boiling Point:626.5 °C at 760 mmHg
- PKA:9.94±0.40(Predicted)
- Flash Point:224.4 °C
- PSA：103.68000
- Density:1.446 g/cm3
- LogP:2.10620
4'-Demethylepipodophyllotoxin (Cas 6559-91-7) Usage
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Description |
4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs. |
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Uses |
4'-demethylepipodophyllotoxin (DMEP) belongs to the class of podophyllotoxin. It is a naturally occurring compound that has been shown to inhibit the mitochondrial membrane potential. |
6559-91-7 Relevant articles
Synthesis and Biological Activity of Ferrocenyl and Ruthenocenyl Analogues of Etoposide: Discovery of a Novel Dual Inhibitor of Topoisomerase II Activity and Tubulin Polymerization
Chrab?szcz, Karolina,B?au?, Andrzej,Grucha?a, Martyna,Wachulec, Marcin,Rychlik, B?a?ej,Pla?uk, Damian
, p. 6254 - 6262 (2021/03/09)
Two series of the ferrocenyl and rutheno...
Isolation, Semisynthesis, and Molecular Modeling of Deoxypodophyllotoxin Analogs for an Anti-oral Cancer Agent
Kim, Eunae,Kim, Hyun Jung,Cho, Seung-Sik,Shim, Jung-Hyun,Yoon, Goo
, p. 472 - 475 (2020/02/13)
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Biotin-podophyllotoxin derivative and its pharmaceutical compositions and methods for their preparation and use
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Paragraph 0040-0041, (2016/10/10)
The invention provides a biotin-podophyl...
6559-91-7 Process route
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![Carbonic acid benzyl ester 4-((5R,5aR,8aR)-6,9-dioxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester](/upload/2023/9/571a7a21-d7ad-4b27-bb3c-56275cf8d16a.png)
- 156350-44-6
Carbonic acid benzyl ester 4-((5R,5aR,8aR)-6,9-dioxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
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- 6559-91-7
4'-demethylepipodophyllotoxin
| Conditions | Yield |
|---|---|
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With ruthenium(II) chloride; (S)-N2,N2'-bis(pyridin-2-ylmethyl-1,1'-binaphthyl-2,2'-diamine); hydrogen; In isopropyl alcohol; at 20 - 25 ℃; for 18h; under 38002.6 Torr;
|
89% |
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- 518-28-5
podofilox
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- 6559-91-7
4'-demethylepipodophyllotoxin
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- 4375-07-9
epipodophyllotoxin
| Conditions | Yield |
|---|---|
|
podofilox; With sodium iodide; In dichloromethane; for 0.0833333h;
With methanesulfonic acid; In dichloromethane; at 0 - 20 ℃;
With barium carbonate; In dichloromethane; water; acetone; at 0 - 20 ℃; for 1h;
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With methanesulfonic acid; sodium iodide; In dichloromethane;
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6559-91-7 Downstream products
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