161797-99-5
- Product Name：ethyl 2-(4-hydroxyphenyl)-4-methyl-5-Thiazolecarboxylate
- Molecular Formula：C13H13NO3S
- Purity：99%
- Molecular Weight：263.317
Product Details;
CasNo： 161797-99-5
Molecular Formula： C13H13NO3S
Quality Manufacturer Supply Sale ethyl 2-(4-hydroxyphenyl)-4-methyl-5-Thiazolecarboxylate 161797-99-5 In Stock
- Molecular Formula:C13H13NO3S
- Molecular Weight:263.317
- Vapor Pressure:0mmHg at 25°C
- Melting Point:180 °C
- Refractive Index:1.598
- Boiling Point:426.819 °C at 760 mmHg
- PKA:8.56±0.15(Predicted)
- Flash Point:211.933 °C
- PSA：87.66000
- Density:1.275 g/cm3
- LogP:3.00080
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate(Cas 161797-99-5) Usage
|
Uses |
Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout. |
InChI:InChI=1/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
161797-99-5 Relevant articles
Benzthiazole-derived chromogenic, fluorogenic and ratiometric probes for detection of hydrazine in environmental samples and living cells
Mahapatra, Ajit Kumar,Karmakar, Parthasarathi,Manna, Srimanta,Maiti, Kalipada,Mandal, Debasish
, p. 1 - 12 (2017)
Benzothiazole-based chromogenic and rati...
A simple and effective ratiometric fluorescent probe for the selective detection of cysteine and homocysteine in aqueous media
Na, Risong,Zhu, Meiqing,Fan, Shisuo,Wang, Zhen,Wu, Xiangwei,Tang, Jun,Liu, Jia,Wang, Yi,Hua, Rimao
, (2016)
Biothiols such as cysteine (Cys) and hom...
Biological evaluation of mitochondria targeting small molecules as potent anticancer drugs
Luo, Shuhua,Dang, Xin,Wang, Juntao,Yuan, Chang,Hu, Yixin,Lei, Shuwen,Zhang, Yang,Lu, Dan,Jiang, Faqin,Fu, Lei
, (2021)
Cancer therapy targets specific metaboli...
Reaction-based ratiometric fluorescent probe for selective recognition of sulfide anions with a large Stokes shift through switching on ESIPT
Karmakar, Parthasarathi,Manna, Srimanta,Ali, Syed Samim,Guria, Uday Narayan,Sarkar, Ripon,Datta, Pallab,Mandal, Debasish,Mahapatra, Ajit Kumar
, p. 76 - 84 (2018)
An ESIPT-based, highly selective, ratiom...
Design, synthesis, cytotoxic evaluation and molecular docking studies of novel thiazolyl α-aminophosphonates
Gundluru, Mohan,Badavath, Vishnu Nayak,Shaik, Haroon Yasmin,Sudileti, Murali,Nemallapudi, Bakthavatchala Reddy,Gundala, Sravya,Zyryanov, Grigory V.,Cirandur, Suresh Reddy
, p. 1139 - 1160 (2021)
Abstract: A new class of thiazolyl α-ami...
Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells
Dang, Xin,Lei, Shuwen,Luo, Shuhua,Hu, Yixin,Wang, Juntao,Zhang, Dongdong,Lu, Dan,Jiang, Faqin,Fu, Lei
, (2021/06/16)
Mitochondria are pivotal energy producti...
Synthesis, molecular docking, DFT study of novel N-benzyl-2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxamide derivatives and their antibacterial activity
Sam Daniel Prabu,Lakshmanan, Sivalingam,Thirumurugan,Ramalakshmi,Arul Antony
, p. 619 - 626 (2020/02/06)
A series of febuxostat based new chemica...
161797-99-5 Process route
-
-
609-15-4
ethyl 2-chloro-3-oxo-butyrate
-
-
161797-99-5
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
| Conditions | Yield |
|---|---|
|
4-cyanophenol;
With
sodium hydroxide; hydrogen sulfide;
In
ethanol;
at 80 ℃;
under 1551.49 - 3102.97 Torr;
With
hydrogenchloride;
In
ethanol;
pH=3.5;
ethyl 2-chloro-3-oxo-butyrate;
In
ethanol;
at 70 ℃;
for 2 - 3h;
Heating / reflux;
|
84.2% |
-
-
25984-63-8
4-hydroxythiobenzamide
-
-
609-15-4
ethyl 2-chloro-3-oxo-butyrate
-
-
161797-99-5
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
| Conditions | Yield |
|---|---|
|
In
ethanol;
at 65 - 70 ℃;
for 3h;
|
98% |
|
In
spirit;
at 60 - 65 ℃;
for 2.5h;
|
90.7% |
|
In
isopropyl alcohol;
at 55 - 85 ℃;
for 3h;
|
58% |
|
In
ethanol;
for 24h;
Heating;
|
|
|
In
isopropyl alcohol;
at 25 - 85 ℃;
|
|
|
In
ethanol;
Reflux;
|
|
|
With
phosphoric acid;
In
ethanol; water;
at 30 - 80 ℃;
|
38 g |
|
In
ethanol;
at 80 ℃;
for 3h;
Solvent;
Temperature;
Green chemistry;
|
24 g |
|
With
PPA;
for 0.25h;
Microwave irradiation;
|
|
|
4-hydroxythiobenzamide; ethyl 2-chloro-3-oxo-butyrate;
In
ethanol;
at 60 - 80 ℃;
With
ammonium hydroxide;
In
water;
at 25 - 30 ℃;
Reagent/catalyst;
|
517.5 g |
|
In
ethanol;
at 80 ℃;
|
|
|
In
ethanol;
at 80 ℃;
|
161797-99-5 Upstream products
-
25984-63-8
4-hydroxythiobenzamide
-
609-15-4
ethyl 2-chloro-3-oxo-butyrate
-
54032-88-1
ethyl 4-methyl-2-[4-(methoxy)phenyl]-1,3-thiazole-5-carboxylate
-
767-00-0
4-cyanophenol
161797-99-5 Downstream products
-
929693-89-0
ethyl 4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazole-5-carboxylate
-
161798-01-2
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
-
144060-53-7
febuxostat
-
161798-02-3
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
Relevant Products
-
FebuxostatCAS：144060-53-7
-
Hydroxyprogesterone CaproateCAS：630-56-8
-
Bisnoralcohol,BACAS：60966-36-1
