160844-75-7
- Product Name：2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid ethyl ester
- Molecular Formula：C18H20N2O3S
- Purity：99%
- Molecular Weight：344.434
Product Details;
CasNo： 160844-75-7
Molecular Formula： C18H20N2O3S
Buy Reliable Quality 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid ethyl ester 160844-75-7 Export In Stock
- Molecular Formula:C18H20N2O3S
- Molecular Weight:344.434
- Vapor Pressure:0mmHg at 25°C
- Melting Point:176 °C
- Refractive Index:1.57
- Boiling Point:497.149 °C at 760 mmHg
- PKA:1.02±0.10(Predicted)
- Flash Point:254.467 °C
- PSA：100.45000
- Density:1.22 g/cm3
- LogP:4.20168
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate(Cas 160844-75-7) Usage
|
Chemical Properties |
White crystalline powder |
|
Uses |
Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout. |
InChI:InChI=1/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3
160844-75-7 Relevant articles
Synthesis, structural elucidation and larvicidal activity of novel arylhydrazones
P, Nefisath,Dasappa, Jagadeesh Prasad,B, Haripriya,Chopra, Deepak,Venugopala, Katharigatta N.,Deb, Pran Kishore,Gleiser, Raquel M.,Mohanlall, Viresh,Maharaj, Rajendra,Shashiprabha,Poojary, Vishwanatha
, (2021)
The present study focuses on a series of...
Febuxostat-based amides and some derived heterocycles targeting xanthine oxidase and COX inhibition. Synthesis, in vitro and in vivo biological evaluation, molecular modeling and in silico ADMET studies
Rashad, Aya Y.,Kassab, Shaymaa E.,Daabees, Hoda G.,Abdel Moneim, Ahmed E.,Rostom, Sherif A.F.
, (2021)
Various febuxostat derivatives comprisin...
Pd/Cu-Catalyzed C-H/C-H Cross Coupling of (Hetero)Arenes with Azoles through Arylsulfonium Intermediates
Lin, Zeng-Hui,Tian, Ze-Yu,Zhang, Cheng-Pan
, p. 4400 - 4405 (2021/06/27)
A highly efficient method for the select...
Improved method for synthesizing febuxostat key intermediate
-
Paragraph 0022-0023, (2021/01/15)
The invention relates to an improved cya...
160844-75-7 Process route
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- 78-77-3
Isobutyl bromide
-
- 161798-02-3
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
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- 160844-75-7
2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
|
With potassium carbonate; potassium iodide; In ethyl acetate; at 65 - 70 ℃; for 5h; Temperature; Solvent; Reagent/catalyst;
|
98.2% |
|
With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 8h;
|
92.9% |
|
With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 3h;
|
88% |
|
With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 3h;
|
88% |
|
With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 15h;
|
2.28 g |
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- 78-77-3
Isobutyl bromide
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- 161798-01-2
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
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- 160844-75-7
2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
|
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate; With hydroxylamine hydrochloride; In dimethyl sulfoxide; at 40 ℃; for 0.5h;
With acetyl chloride; In dimethyl sulfoxide; at 70 - 80 ℃;
Isobutyl bromide; With potassium carbonate; In dimethyl sulfoxide; at 20 - 80 ℃;
|
84% |
|
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate; With hydroxylamine hydrochloride; In dimethyl sulfoxide; for 0.5h;
With acetyl chloride; In dimethyl sulfoxide; at 70 - 80 ℃;
Isobutyl bromide; With potassium carbonate; In dimethyl sulfoxide; at 70 - 80 ℃; for 5h;
|
84% |
160844-75-7 Upstream products
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609-15-4
ethyl 2-chloro-3-oxo-butyrate
-
163597-57-7
3-cyanoisobutoxybenzothioamide
-
161718-81-6
4-isobutoxyisophthalonitrile
-
619-72-7
4-nitrobenzonitrile
160844-75-7 Downstream products
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144060-53-7
febuxostat
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1350352-71-4
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine
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1350352-72-5
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine
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1140907-14-7
febuxostat potassium
Relevant Products
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FebuxostatCAS：144060-53-7
-
LevonorgestrelCAS：797-63-7
-
AbirateroneCAS：154229-19-3
