259793-96-9
- Product Name：Favipiravir
- Molecular Formula：C5H4FN3O2
- Purity：99%
- Molecular Weight：157.104
Product Details;
CasNo： 259793-96-9
Molecular Formula： C5H4FN3O2
Buy Reliable Quality Favipiravir 259793-96-9 Export with Best Price
- Molecular Formula:C5H4FN3O2
- Molecular Weight:157.104
- Boiling Point:552.6 °C at 760 mmHg
- PKA:8.77±0.60(Predicted)
- Flash Point:288 °C
- PSA：88.84000
- Density:1.78 g/cm3
- LogP:-0.29180
259793-96-9 Relevant articles
Preparation method of favipiravir
-
Paragraph 0045-0057, (2021/08/14)
The invention relates to a preparation m...
Scalable synthesis of favipiravir: Via conventional and continuous flow chemistry
Charoensetakul, Netnapa,Khamkhenshorngphanuch, Thitiphong,Srikun, Onsiri,Srimongkolpithak, Nitipol,Thongpanchang, Chawanee,Tiyasakulchai, Thanat,Yuthavong, Yongyuth
, p. 38691 - 38693 (2021/12/20)
Decagram scale synthesis of favipiravir ...
Refining method of favipiravir
-
Paragraph 0029-0036, (2021/04/14)
The invention provides a refining method...
PROCESS FOR PREPARATION OF FAVIPIRAVIR
-
Paragraph 0261, (2021/12/08)
The present invention relates to a proce...
259793-96-9 Process route
-
-
356783-31-8
6-fluoro-3-hydroxypyrazine-2-carbonitrile
-
-
259793-96-9
favipiravir
| Conditions | Yield |
|---|---|
|
6-fluoro-3-hydroxypyrazine-2-carbonitrile;
With
sulfuric acid;
at 50 ℃;
for 4h;
With
water;
at 3 - 10 ℃;
for 0.666667h;
With
sodium hydroxide;
In
water;
at 10 ℃;
for 0.75h;
|
92.3% |
|
With
sodium hydroxide;
In
water;
at 5 - 45 ℃;
for 5.5h;
Large scale;
|
91% |
|
With
dihydrogen peroxide; sodium hydroxide;
In
water;
at 50 - 60 ℃;
Temperature;
|
85.8% |
|
With
sulfuric acid;
at 50 ℃;
for 4h;
|
68.43% |
|
With
sulfuric acid; water; sodium hydroxide;
at 50 ℃;
for 4h;
|
61% |
|
6-fluoro-3-hydroxypyrazine-2-carbonitrile;
With
dihydrogen peroxide; sodium hydroxide;
at 10 - 20 ℃;
for 1h;
With
N-ethyl-N,N-diisopropylamine;
In
ethyl acetate;
at 80 ℃;
for 1h;
Reagent/catalyst;
|
|
|
6-fluoro-3-hydroxypyrazine-2-carbonitrile;
With
water; sodium hydroxide;
at 15 - 25 ℃;
for 0.5h;
With
dihydrogen peroxide;
In
water;
at 15 - 35 ℃;
for 3h;
|
4.9 g |
|
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; isopropyl alcohol / 1 h / 10 - 20 °C
2.1: sodium hydroxide; water / 0.5 h / 15 - 25 °C
2.2: 1 h / 15 - 35 °C
With
water; sodium hydroxide;
In
water; isopropyl alcohol;
|
|
|
With
dihydrogen peroxide; sodium hydroxide;
In
water; dimethyl sulfoxide;
at 0 - 40 ℃;
for 1h;
|
1.65 g |
-
-
356783-29-4
3,6-difluoropyrazine-2-carboxamide
-
-
259793-96-9
favipiravir
| Conditions | Yield |
|---|---|
|
With
water; sodium hydroxide;
at 60 ℃;
for 3h;
|
92.1% |
|
With
sodium hydrogencarbonate;
In
1,4-dioxane; water;
at 60 ℃;
for 8h;
|
82% |
|
With
water; sodium hydrogencarbonate;
at 50 ℃;
for 8.5h;
|
65% |
|
With
water; sodium hydrogencarbonate;
at 50 ℃;
for 8.5h;
Reagent/catalyst;
|
65% |
|
With
water; sodium hydrogencarbonate;
In
dimethyl sulfoxide;
at 50 ℃;
for 8h;
|
0.25 g |
|
With
methanol; water; sodium hydrogencarbonate;
at 50 ℃;
for 8h;
|
11.82 g |
|
With
water; sodium hydrogencarbonate;
In
tetrahydrofuran; methanol;
at 20 - 60 ℃;
|
259793-96-9 Upstream products
-
55321-99-8
3-hydroxy-2-pyrazinecarboxamide
-
356783-27-2
methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate
-
356783-31-8
6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile
-
356783-42-1
3-amino-6-fluoro-2-pyrazinecarboxamide
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