356783-28-3
- Product Name：3,6-Difluoropyrazine-2-carbonitrile
- Molecular Formula：C5HF2N3
- Purity：99%
- Molecular Weight：141.08
Product Details;
CasNo： 356783-28-3
Molecular Formula： C5HF2N3
Buy High Quality 3,6-Difluoropyrazine-2-carbonitrile 356783-28-3 Export with Safe Transportation
- Molecular Formula:C5HF2N3
- Molecular Weight:141.08
- Boiling Point:206.5±35.0 °C(Predicted)
- PKA:-7.28±0.10(Predicted)
- PSA：49.57000
- Density:1.47±0.1 g/cm3(Predicted)
- LogP:0.62648
356783-28-3 Relevant articles
Scalable synthesis of favipiravir: Via conventional and continuous flow chemistry
Charoensetakul, Netnapa,Khamkhenshorngphanuch, Thitiphong,Srikun, Onsiri,Srimongkolpithak, Nitipol,Thongpanchang, Chawanee,Tiyasakulchai, Thanat,Yuthavong, Yongyuth
, p. 38691 - 38693 (2021/12/20)
Decagram scale synthesis of favipiravir ...
Preparation method of 6 -fluoro -3 -hydroxypyrazine -2 - formamide
-
Paragraph 0023-0025, (2021/12/07)
The invention provides a preparation met...
PROCESS FOR THE PREPARATION OF 3,6-DICHLOROCYANO PYRAZINE, 3,6-DIOXOPIPERAZINE DERIVATIVES AND PRODUCTION OF FAVIPIRAVIR THEREOF
-
, (2021/12/31)
The present invention relates to a metho...
METHODS FOR PREPARING FAVIPIRAVIR
-
Paragraph 0017; 0333; 0334, (2021/11/20)
The present invention provides methods f...
356783-28-3 Process route
-
-
356783-16-9
3,6-dichloropyrazine-2-carbonitrile
-
-
356783-28-3
3,6-difluoropyrazine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide;
at 60 ℃;
for 3h;
|
98% |
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide; toluene;
at 60 ℃;
for 2.5h;
|
92.3% |
|
With
potassium fluoride;
In
dimethyl sulfoxide;
at 60 - 90 ℃;
Large scale;
|
85% |
|
With
tetrabutyl ammonium fluoride; tetrabutylammomium bromide;
at 60 ℃;
for 3h;
Reagent/catalyst;
Temperature;
Solvent;
Sealed tube;
|
62.37% |
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide;
at 60 ℃;
|
60% |
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide;
at 55 ℃;
for 3h;
Sealed tube;
|
52.8% |
|
With
potassium fluoride; sodium chloride; tetrabutylammomium bromide;
In
water; dimethyl sulfoxide; ethyl acetate;
|
|
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide; toluene;
at 55 ℃;
for 3h;
|
|
|
With
potassium fluoride dihydrate; tetrabutylammomium bromide;
In
dimethyl sulfoxide;
at 50 ℃;
for 3h;
|
|
|
With
potassium fluoride; tetrabutyl ammonium fluoride;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 12h;
|
-
-
1257072-34-6
6-bromo-3-chloropyrazine-2-carbonitrile
-
-
356783-28-3
3,6-difluoropyrazine-2-carbonitrile
| Conditions | Yield |
|---|---|
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide; toluene;
at 70 - 100 ℃;
for 4h;
|
49% |
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide; toluene;
at 70 - 100 ℃;
for 4h;
|
49% |
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide;
at 70 - 100 ℃;
for 4h;
|
49% |
|
With
potassium fluoride; tetrabutylammomium bromide;
In
dimethyl sulfoxide; toluene;
at 70 - 100 ℃;
for 3h;
|
49% |
356783-28-3 Upstream products
-
356783-16-9
3,6-dichloropyrazine-2-carbonitrile
-
356783-59-0
6-fluoro-3-(phenylsulfonyl)-2-pyrazinecarbonitrile
-
55321-99-8
3-hydroxy-2-pyrazinecarboxamide
-
1257072-34-6
6-bromo-3-chloropyrazine-2-carbonitrile
356783-28-3 Downstream products
-
356783-29-4
3,6-difluoropyrazine-2-carboxamide
-
356783-31-8
6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile
-
356783-45-4
6-fluoro-3-methoxy-2-pyrazinecarbonitrile
-
1137606-74-6
dicyclohexylamine salt
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