184177-83-1
- Product Name：2-[(1S,2S)-1-Ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
- Molecular Formula：C30H35N5O3
- Purity：99%
- Molecular Weight：513.64
Product Details;
CasNo： 184177-83-1
Molecular Formula： C30H35N5O3
Appearance： Grey solid
Factory Supply Best Quality 2-[(1S,2S)-1-Ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one 184177-83-1 Competitive Price
- Molecular Formula:C30H35N5O3
- Molecular Weight:513.64
- Appearance/Colour:Grey solid
- Refractive Index:1.632
- Boiling Point:685.351 °C at 760 mmHg
- PKA:12.18±0.30(Predicted)
- Flash Point:368.287 °C
- PSA：75.76000
- Density:1.224 g/cm3
- LogP:4.75260
2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one,(Cas 184177-83-1) Usage
|
Chemical Properties |
Grey Solid |
|
Uses |
Intermediate in the preparation of Posaconazole (P689600). |
InChI:InChI=1/C30H35N5O3/c1-3-29(23(2)38-21-24-7-5-4-6-8-24)35-30(37)34(22-31-35)27-11-9-25(10-12-27)32-17-19-33(20-18-32)26-13-15-28(36)16-14-26/h4-16,22-23,29,36H,3,17-21H2,1-2H3/t23-,29+/m1/s1
184177-83-1 Relevant articles
An Improved Scalable Preparation of the Antifungal Posaconazole
Jha, Anjali,Krishnam Raju, V. R.
, (2021/11/12)
-
Preparation method of posaconazole intermediate
-
Paragraph 0029-0031; 0036-0037, (2021/04/21)
The invention discloses a preparation me...
Preparation method of posaconazole
-
Paragraph 0057-0065, (2020/09/30)
The invention discloses a preparation me...
A PROCESS FOR THE MANUFACTURE OF POSACONAZOLE
-
Page/Page column 12; 22; 23, (2019/05/10)
The present invention discloses an impro...
184177-83-1 Process route
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-
184177-81-9
phenyl N-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)carbamate
-
![N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide](/upload/2023/9/ed467af6-d918-4f17-88d3-e554a6435be2.png)
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170985-85-0
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
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![2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one](/upload/2023/9/94f71beb-c2ab-4982-aed1-0253a252fa89.png)
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184177-83-1
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
1,4-dioxane;
at 90 - 100 ℃;
for 24h;
|
70% |
|
With
triethylamine;
In
1,4-dioxane;
at 90 - 95 ℃;
Large scale;
|
0.89 kg |
|
With
triethylamine;
In
1,4-dioxane;
at 90 - 100 ℃;
for 24h;
|
|
|
With
triethylamine;
In
acetonitrile;
at 65 ℃;
for 30h;
|
-
-
2-((2S,3S)-2-(benzyloxy)-3-pentyl)-4-(4-(4-(4-aminophenyl)piperazin-1-yl)phenyl)-2,4-dihydro-1,2,4-triazole-3(4H)-one
-
-
184177-83-1
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; sodium nitrite;
In
water;
at 0 - 80 ℃;
Inert atmosphere;
|
80% |
184177-83-1 Upstream products
-
184177-81-9
phenyl N-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)carbamate
-
170985-85-0
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
-
74853-08-0
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
-
77287-11-7
methyl (S)-2-(benzyloxy)propanoate
184177-83-1 Downstream products
-
170985-86-1
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
-
171228-49-2
posaconazote
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