2322-77-2
- Product Name:18-Methyl-3-methoxy-2, 5(10)-estradien-17-one
- Molecular Formula:C20H28O2
- Purity:99%
- Molecular Weight:300.441
Product Details;
CasNo: 2322-77-2
Molecular Formula: C20H28O2
Appearance: White to Off-White Crystalline Powder
Factory supply 18-Methyl-3-methoxy-2, 5(10)-estradien-17-one 2322-77-2 with low price
- Molecular Formula:C20H28O2
- Molecular Weight:300.441
- Appearance/Colour:White to Off-White Crystalline Powder
- Vapor Pressure:3.21E-08mmHg at 25°C
- Melting Point:≥170oC
- Refractive Index:1.551
- Boiling Point:448 °C at 760 mmHg
- Flash Point:188.8 °C
- PSA:26.30000
- Density:1.09 g/cm3
- LogP:4.80260
Methoxydienone(Cas 2322-77-2) Usage
|
Flammability and Explosibility |
Nonflammable |
InChI:InChI=1/C20H28O2/c1-3-20-11-10-16-15-7-5-14(22-2)12-13(15)4-6-17(16)18(20)8-9-19(20)21/h5,16-18H,3-4,6-12H2,1-2H3/t16-,17-,18+,20+/m1/s1
2322-77-2 Relevant articles
SILICA GEL PROMOTED SELECTIVE HYDROLYSIS OF 3-METHOXY-2,5(10)-DIENE STEROIDS
Lui, Li-Gong,Zhang, Tong,Li, Zhen-Su
, p. 2999 - 3006 (2007/10/03)
Hydrolysis of 3-methoxy-2,5(10)-diene st...
Total synthesis with a chirogenic opening move demonstrated on steroids with estrane or 18a-homoestrane skeleton
Quinkert,Del Grosso,Doring,Doring,Schenkel,Bauch,Dambacher,Bats,Zimmermann,Durner
, p. 1345 - 1391 (2007/10/02)
A concept of first choice for the synthe...
Aromatization of dl-3-methoxy-13β-ethylgona-2,5(10)-dien-17β-ol
Sharma,Chatterjee
, p. 158 - 159 (2007/10/02)
-
Total-synthesis of (-)-norgestrel
Baier,Durner,Quinkert
, p. 1054 - 1068 (2007/10/02)
-
2322-77-2 Process route
-
-
1038-28-4,5772-35-0,14507-49-4,77209-48-4,85798-56-7
dl-3-methoxy-13β-ethylgona-2,5(10)-dien-17β-ol
-
-
2322-77-2,6236-40-4,17092-08-9,19640-64-3
dl-3-methoxy-13β-ethylgona-2,5(10)-dien-17-one
| Conditions | Yield |
|---|---|
|
With
molecular sieve; aluminum isopropoxide; butanone;
In
benzene;
|
76% |
|
With
cyclohexanone; aluminum isopropoxide;
In
toluene;
Heating;
|
-
-
2-Ethyl-3-vinyl-cyclopentanone
-
-
2322-77-2,6236-40-4,17092-08-9,19640-64-3
dl-3-methoxy-13β-ethylgona-2,5(10)-dien-17-one
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 5 steps
1: 80 percent NaH, Et3N / 1,2-dimethoxy-ethane; paraffin / 1.) 3.5 h, reflux; 2.) 40 min
2: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation
3: 99 percent / LiAlH4 / diethyl ether
4: 62 percent / K, aniline, NH3 / tetrahydrofuran / 1 h
5: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene
With
pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; ammonia; oxalic acid; aluminum isopropoxide; sodium hydride; triethylamine; aniline; butanone;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; paraffin; benzene;
|
|
|
Multi-step reaction with 6 steps
1: 86 percent / TsOH*H2O / 14 h / Heating
2: 1.) 1.3 M MeLi; 2.) 10 percent H2SO4 / 1.) Et2O, 0.5 h; -20 deg C, 3h; 2.) Et2O, 14 h, RT
3: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation
4: 99 percent / LiAlH4 / diethyl ether
5: 62 percent / K, aniline, NH3 / tetrahydrofuran / 1 h
6: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene
With
pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; sulfuric acid; ammonia; methyllithium; oxalic acid; aluminum isopropoxide; toluene-4-sulfonic acid; aniline; butanone;
In
tetrahydrofuran; diethyl ether; benzene;
|
|
|
Multi-step reaction with 5 steps
1: 1.) NaH, 2.) H2SO4 / 1.) DME, paraffin oil; Et2O; 2.) MeOH
2: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation
3: 99 percent / LiAlH4 / diethyl ether
4: 62 percent / K, aniline, NH3 / tetrahydrofuran / 1 h
5: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene
With
pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; sulfuric acid; ammonia; oxalic acid; aluminum isopropoxide; sodium hydride; aniline; butanone;
In
tetrahydrofuran; diethyl ether; benzene;
|
2322-77-2 Upstream products
-
14507-49-4
D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene
-
7443-72-3
18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol
-
75863-25-1
2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)prop-2-en-1-on
-
101025-85-8
13-Ethyl-3-methoxy-6,7:8,9-disecogona-1,3,5(10),7-tetraen-9,17-dion
2322-77-2 Downstream products
-
799-43-9
13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol
-
797-63-7
levonorgestrel
-
14507-51-8
13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol
-
4222-96-2
DL-13β-ethyl-gon-5(10)-ene-3,17-dione
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