2097518-76-6
- Product Name:((2R,7as)-2-fluorotetrahydro-1h-pyrrolizin-7a(5h)-yl)methanol
- Molecular Formula:
- Purity:99%
- Molecular Weight:159.204
Product Details;
CasNo: 2097518-76-6
Manufacturer Sells Best Quality ((2R,7as)-2-fluorotetrahydro-1h-pyrrolizin-7a(5h)-yl)methanol 2097518-76-6 with stock
- Molecular Formula:C8H14FNO
- Molecular Weight:159.204
2097518-76-6 Relevant articles
KRAS G12D INHIBITORS
-
Paragraph 0198, (2022/02/15)
The present invention relates to compoun...
QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
-
, (2022/01/12)
Provided herein are novel compounds, for...
KRAS G12D INHIBITORS
-
Paragraph 0512, (2021/03/05)
The present invention relates to compoun...
KRAS G12C INHIBITORS
-
, (2020/07/25)
The present invention relates to compoun...
2097518-76-6 Process route
-
-
rac-ethyl (2R,7aS)‐2-fluoro-5-oxotetrahydro-1H-pyrrolizine-7a(5H)-carboxylate
-
-
2097518-76-6
rac-((2R,7aS)‐2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
| Conditions | Yield |
|---|---|
|
With
lithium aluminium hydride;
In
tetrahydrofuran;
at 0 - 70 ℃;
for 3h;
Inert atmosphere;
|
94.7% |
|
With
lithium aluminium hydride;
In
tetrahydrofuran;
at 0 - 70 ℃;
for 3h;
Inert atmosphere;
|
94.7% |
|
With
lithium aluminium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 4h;
Inert atmosphere;
Reflux;
|
|
|
With
lithium aluminium hydride;
In
tetrahydrofuran;
at 0 - 70 ℃;
for 4h;
|
-
-
(2R,7aR)-7a-(((tert-butyldiphenylsilyl)oxy)methyl)-2-fluorohexahydro-1H-pyrrolizine
-
-
2097518-76-6
((2R,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
| Conditions | Yield |
|---|---|
|
With
cesium fluoride;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 20h;
|
90% |
2097518-76-6 Upstream products
-
251924-83-1
1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate
-
66183-71-9
ethyl 2-oxopyrrolidine-5-carboxylate
-
868066-08-4
ethyl 5-oxo-2-(2-chloromethylprop-2-enyl)pyrrolidine-2-carboxylate
-
942603-91-0
ethyl 2-methylene-5-oxotetrahydro-1H-pyrrolizine-7a(5H)-carboxylate
2097518-76-6 Downstream products
-
2621928-55-8
4-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol
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