2097518-76-6

  • Product Name:((2R,7as)-2-fluorotetrahydro-1h-pyrrolizin-7a(5h)-yl)methanol
  • Molecular Formula:
  • Purity:99%
  • Molecular Weight:159.204
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Product Details;

CasNo: 2097518-76-6

Manufacturer Sells Best Quality ((2R,7as)-2-fluorotetrahydro-1h-pyrrolizin-7a(5h)-yl)methanol 2097518-76-6 with stock

  • Molecular Formula:C8H14FNO
  • Molecular Weight:159.204

2097518-76-6 Relevant articles

KRAS G12D INHIBITORS

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Paragraph 0198, (2022/02/15)

The present invention relates to compoun...

QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

-

, (2022/01/12)

Provided herein are novel compounds, for...

KRAS G12D INHIBITORS

-

Paragraph 0512, (2021/03/05)

The present invention relates to compoun...

KRAS G12C INHIBITORS

-

, (2020/07/25)

The present invention relates to compoun...

2097518-76-6 Process route

rac-ethyl (2R,7aS)‐2-fluoro-5-oxotetrahydro-1H-pyrrolizine-7a(5H)-carboxylate

rac-ethyl (2R,7aS)‐2-fluoro-5-oxotetrahydro-1H-pyrrolizine-7a(5H)-carboxylate

rac-((2R,7aS)‐2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
2097518-76-6

rac-((2R,7aS)‐2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol

Conditions
Conditions Yield
With lithium aluminium hydride; In tetrahydrofuran; at 0 - 70 ℃; for 3h; Inert atmosphere;
94.7%
With lithium aluminium hydride; In tetrahydrofuran; at 0 - 70 ℃; for 3h; Inert atmosphere;
94.7%
With lithium aluminium hydride; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere; Reflux;
With lithium aluminium hydride; In tetrahydrofuran; at 0 - 70 ℃; for 4h;
(2R,7aR)-7a-(((tert-butyldiphenylsilyl)oxy)methyl)-2-fluorohexahydro-1H-pyrrolizine

(2R,7aR)-7a-(((tert-butyldiphenylsilyl)oxy)methyl)-2-fluorohexahydro-1H-pyrrolizine

((2R,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
2097518-76-6

((2R,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol

Conditions
Conditions Yield
With cesium fluoride; In N,N-dimethyl-formamide; at 50 ℃; for 20h;
90%

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