33419-42-0
- Product Name：Etoposide
- Molecular Formula：C29H32O13
- Purity：99%
- Molecular Weight：588.565
Product Details;
CasNo： 33419-42-0
Molecular Formula： C29H32O13
Appearance： White crystalline powder
Quality products make an important contribution to long-term revenue and profitability. Factory Supply Industrial Grade Etoposide 33419-42-0 with Best Price
1.What is the Etoposide ?
Etoposide (VePesid) is a semisynthetic derivative of podophyllotoxin that is produced in the roots of the American mandrake, or May apple. Unlike podophyllotoxin and vinca alkaloids, etoposide does not bind to microtubules. It forms a complex with the enzyme topoisomerase II, which results in a single-strand breakage of DNA. It is most lethal to cells in the S- and G2-phases of the cell cycle. Drug resistance to etoposide is thought to be caused by decreased cellular drug accumulation. Etoposide is most useful against testicular and ovarian germ cell cancers, lymphomas, small cell lung cancers, and acute myelogenous and lymphoblastic leukemia.Toxicities include mild nausea, alopecia, allergic reaction, phlebitis at the injection site, and bone marrow toxicity.
anticonvulsant
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217475-21-3
2''-3''-di-O-benzyletoposide
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33419-42-0
etoposide
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
under 2585.81 Torr;
|
96.8% |
|
With
hydrogen;
5%-palladium/activated carbon;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
under 2585.81 Torr;
Product distribution / selectivity;
Buchi apparatus;
|
96.8% |
|
With
hydrogen;
5%-palladium/activated carbon;
In
acetone;
at 20 ℃;
for 1h;
under 2250.23 Torr;
Product distribution / selectivity;
|
93.3% |
|
With
hydrogen;
Pd/C;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 3.5h;
under 2585.81 Torr;
Product distribution / selectivity;
Parr-shaker bottle;
|
92.5% |
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![Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-bis-benzyloxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester](/upload/2026/9/cf6e5703-aa78-4642-a513-3ab1a19fa016.png)
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270928-23-9
Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-bis-benzyloxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester
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33419-42-0
etoposide
| Conditions | Yield |
|---|---|
|
With
hydrogen; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; ethyl acetate;
for 12h;
under 2585.81 Torr;
|
85% |
2.What is the CAS number for Etoposide ?
The CAS number of Etoposide is 33419-42-0.
More information of Etoposide 33419-42-0 are:
|
CAS Number |
33419-42-0 |
|
Density |
1.55 g/cm3 |
|
Melting Point |
236-251 °C(lit.) |
|
Boiling Point |
798.054 °C at 760 mmHg |
|
Flash Point |
263.603 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.662 |
|
HS CODE |
29389090 |
|
PSA |
160.83000 |
|
LogP |
1.33860 |
|
Pka |
9.8(at 25℃) |
3.What are another words for Etoposide ?
Synonyms for Etoposide 33419-42-0:Etoposide; 4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside); 4‘-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside);
4.What is the molecular formula of Etoposide?
The chemical formula of Etoposide is C29H32O13 which containing 29 Carbon atoms,32 Hydrogen atoms and 13 Oxygen atoms,and the molecular weight of Etoposide is 588.565.
5.What is Etoposide (33419-42-0) used for?
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 μM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 μM). It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A . Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 μM). Formulations containing etoposide have been used in combination therapy in the treatment of cancer.
Relevant articles related to Etoposide:
|
Article |
Source |
|
Real-time monitoring of etoposide prodrug activated by hydrogen peroxide with improved safety |
Zhu, Jiawen,Chen, Jingting,Song, Dongmei,Zhang, Wenda,Guo, Jianpeng,Cai, Guiping,Ren, Yuhao,Wan, Chengying,Kong, Lingyi,Yu, Wenying , p. 7548 - 7557 (2019) |
|
Analogues of Etoposide for the Treatment of Tumours |
- Paragraph 0062; 0063, (2013/06/04) |
6.Buy Etoposide with the best price .
Golden Pharma Co., Limited is a quality supplier of Etoposide. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Etoposide 33419-42-0.
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