41575-94-4
- Product Name：Carboplatin
- Molecular Formula：C6H12N2O4Pt
- Purity：99%
- Molecular Weight：371.252
Product Details;
CasNo： 41575-94-4
Molecular Formula： C6H12N2O4Pt
Appearance： White Crystals
Quality products make an important contribution to long-term revenue and profitability. Quality manufacturer supply Carboplatin 41575-94-4 in stock with high standard
1.What is the Carboplatin ?
Carboplatin (Paraplatin) is an analogue of cisplatin. Its plasma half-life is 3 to 5 hours, and it has no significant protein binding. Renal excretion is the major route of drug elimination. Despite its lower chemical reactivity, carboplatin has antitumor activity that is similar to that of cisplatin against ovarian carcinomas, small cell lung cancers, and germ cell cancers of the testis. Most tumors that are resistant to cisplatin are cross-resistant to carboplatin. The major advantage of carboplatin over cisplatin is a markedly reduced risk of toxicity to the kidneys, peripheral nerves, and hearing; additionally, it produces less nausea and vomiting. It is, however, more myelosuppressive than cisplatin. Other adverse effects include anemia, abnormal liver function tests, and occasional allergic reactions.
Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic
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-
cis-diaminediiodoplatinum(II)
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-
5445-51-2
cyclobutane-1,1'-dicarboxylic acid
-
-
41575-94-4
carboplatinum
| Conditions | Yield |
|---|---|
|
With
barium dihydroxide; silver sulfate;
In
water;
byproducts: AgI, BaSO4; addn. of Ag2SO4 to slight excess of Pt-complex, stirring (4 h), filtration off of AgI, concn., addn. of soln. of ligand (neutralized with Ba(OH)2); filtration off of BaSO4, concn. (crystn.), washing (EtOH, Et2O), drying(vac.); elem. anal.;
|
88% |
|
cis-diaminediiodoplatinum(II);
With
silver sulfate;
In
water;
for 4h;
cyclobutane-1,1'-dicarboxylic acid;
With
barium hydroxide octahydrate;
In
water;
|
85% |
|
cis-diaminediiodoplatinum(II);
With
silver nitrate;
In
water;
Darkness;
cyclobutane-1,1'-dicarboxylic acid;
With
potassium hydroxide;
for 3h;
pH=5;
|
50.3% |
|
With
potassium hydroxide;
In
water; N,N-dimethyl-formamide;
Pt-compd. dissolved in DMF with heating, addn. of the acid and aq. KOH, heated in an unstoppered flask at 60°C for 20 h; cooled, filtered, addn. of ether;
|
40% |
-
-
cis-diaminediiodoplatinum(II)
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-
1,1-cyclobutanedicarboxylic acid disilver salt
-
-
41575-94-4
carboplatinum
| Conditions | Yield |
|---|---|
|
In
ethanol; water;
at 20 ℃;
for 48h;
Darkness;
|
48% |
|
In
water;
byproducts: AgI; Pt- and Ag-complex mixed together in water, stirred in dark for 2-3 d; ppt. filtered, filtrate evapd. to dryness;
|
|
|
In
water;
for 2 - 3h;
|
2.What is the CAS number for Carboplatin ?
The CAS number of Carboplatin is 41575-94-4.
More information of Carboplatin 41575-94-4 are:
|
CAS Number |
41575-94-4 |
|
Melting Point |
228-230 °C |
|
Boiling Point |
366.4oCat 760 mmHg |
|
Flash Point |
189.6oC |
|
HS CODE |
28439000 |
|
PSA |
59.08000 |
|
LogP |
0.81700 |
3.What are another words for Carboplatin ?
Synonyms for Carboplatin 41575-94-4:Platinum, diammine[1, 1-cyclobutanedicarboxylato (2-)-O,O]-, (SP-4-2)-;Paraplatin (TN);Platinum(II), (1, 1-cyclobutanedicarboxylato)diammine-, cis-;(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O]platinum;Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II);Platinum, diamine(1, 1-cyclobutanedicarboxylato(2-)-O,O)-, (SP-4-2)-;Cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II);azanide; cyclobutane-1,1-dicarboxylic acid; platinum;Paraplatin;cis- (1,1-Cyclobutanedicarboxylato)diammineplatinum(II);Platinum,diammine[1,1-cyclobutanedi(carboxylato- kO)(2-)]-,(SP-4-2)-;Carboplatin (USAN);cis-Diammine (1,1-cyclobutanedicarboxylato)platinum(II);Carboplatin (JAN/USP);1, 1-Cyclobutanedicarboxylate diammine platinum (II);diammine[cyclobutane-1,1-dicarboxylato(2-)-O,O']platinum;
4.What is the molecular formula of Carboplatin?
The chemical formula of Carboplatin is C6H12N2O4Pt which containing 6 Carbon atoms,12 Hydrogen atoms,2 Nitrogen atoms,4 Oxygen atoms and 1 Platinum atoms,and the molecular weight of Carboplatin is 371.252.
5.What is Carboplatin (41575-94-4) used for?
Carboplatin is a second generation, platinum-containing antineoplastic agent with significantly reduced nephro-, neuro-, and ototoxicity in comparison to cisplatin. It is effective in the treatment of advanced ovarian carcinoma of epithelial origin and small cell carcinoma of the lung.
InChI:InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+4/p-2/rC6H10N2O4Pt/c7-13(8)11-4(9)6(2-1-3-6)5(10)12-13/h1-3,7-8H2
Relevant articles related to Carboplatin:
|
Article |
Source |
|
Synthesis of monofunctional platinum(iv) carboxylate precursors for use in Pt(iv)-peptide bioconjugates |
?mi?owicz, Dariusz,Metzler-Nolte, Nils , p. 15465 - 15476 (2018) |
|
BODI-Pt, a Green-Light-Activatable and Carboplatin-Based Platinum(IV) Anticancer Prodrug with Enhanced Activation and Cytotoxicity |
Chen, Shu,Deng, Zhiqin,Matsuda, Yudai,Tse, Man-Kit,Yao, Houzong,Zhu, Guangyu supporting information, (2020/09/02) |
6.Buy Carboplatin with the best price .
Golden Pharma Co., Limited is a quality supplier of Carboplatin. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Carboplatin 41575-94-4.
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