54048-10-1
- Product Name：Etonogestrel
- Molecular Formula：C22H28O2
- Purity：99%
- Molecular Weight：324.463
Product Details;
CasNo： 54048-10-1
Molecular Formula： C22H28O2
Appearance： White Solid
Manufacturer supply top purity Etonogestrel 54048-10-1 with ISO standards
- Molecular Formula:C22H28O2
- Molecular Weight:324.463
- Appearance/Colour:White Solid
- Vapor Pressure:6.13E-11mmHg at 25°C
- Melting Point:182-184 °C
- Refractive Index:1.574
- Boiling Point:473.1 °C at 760 mmHg
- PKA:13.04±0.40(Predicted)
- Flash Point:201.1 °C
- PSA：37.30000
- Density:1.13 g/cm3
- LogP:4.04870
Etonogestrel(Cas 54048-10-1) Usage
|
Biochem/physiol Actions |
Etonogestrel is a lipophilic molecule. Pharmacokinetics studies reveal that etonogestrel is bound to protein albumin in the blood. This remains independent of both endogenous and exogenous concentration of estradiol. |
|
Brand name |
Implanon (Organon). |
|
General Description |
Etonogestrel, 17α-13-ethyl-17hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one,3-ketodesogestrel, is the active metabolite of desogestrel. It isthe progestin component in a newer implantable contraceptive(Implanon) and in the vaginal contraceptive ring (NuvaRing). |
InChI:InChI=1/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
54048-10-1 Relevant articles
PROCESS AND NEW INTERMEDIATES FOR THE PREPARATION OF 11-METHYLENE STEROIDS
-
Page/Page column 33, (2017/09/19)
The invention relates to a process for t...
COMBINED SYNTHESIS ROUTE FOR ETONOGESTREL AND DESOGESTREL
-
, (2013/09/26)
The present invention relates to a synth...
KIT FOR FEMALE MAMMALS, COMPRISING A COMBINATION OF GESTAGEN AND OESTROGEN
-
, (2008/06/13)
-
Pharmaceutical combined preparation, kit and method for hormonal contraception
-
, (2008/06/13)
PCT No. PCT/DE96/01192 Sec. 371 Date Jun...
54048-10-1 Process route
-
-
13β-ethyl-17α-hydroxy-11-methylene-, cyclic 1,2-ethanediyldithioacetal-18,19-dinorpregn-4-en-20-yn-3-one
-
-
54048-10-1
etonogestrel
| Conditions | Yield |
|---|---|
|
With
water;
In
tetrahydrofuran; methanol;
at 2 ℃;
for 2.5h;
Concentration;
Reagent/catalyst;
Solvent;
Time;
Temperature;
|
98% |
-
-
C25H40O3Si
-
-
1066-54-2
trimethylsilylacetylene
-
-
54048-10-1
etonogestrel
| Conditions | Yield |
|---|---|
|
trimethylsilylacetylene;
With
n-hexyllithium;
In
tetrahydrofuran; n-heptane;
at -5 ℃;
for 0.5h;
C25H40O3Si;
In
tetrahydrofuran; n-heptane;
for 15h;
Further stages;
|
2.1 g |
54048-10-1 Upstream products
-
187538-71-2
Acetic acid (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
-
54024-22-5
desogestrel
-
160683-92-1
18a-homo-estr-4-ene-11α,17β-diol
-
54024-21-4
11-methylene-18a-homo-estr-4-en-17-one
54048-10-1 Downstream products
-
70805-85-5
3alpha-Hydroxydesogestrel
-
70805-85-5
13-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yne-3β-17β-diol
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-
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