137234-74-3
- Product Name：4-chloro-6-ethyl-5-fluoropyrimidine
- Molecular Formula：C6H6ClFN2
- Purity：99%
- Molecular Weight：160.578
Product Details;
CasNo： 137234-74-3
Molecular Formula： C6H6ClFN2
Quality Factory Supply High Purity 99% 4-chloro-6-ethyl-5-fluoropyrimidine 137234-74-3 Safe Transportation
- Molecular Formula:C6H6ClFN2
- Molecular Weight:160.578
- Vapor Pressure:0.272mmHg at 25°C
- Refractive Index:1.502
- Boiling Point:210.913 °C at 760 mmHg
- PKA:-0.45±0.26(Predicted)
- Flash Point:81.358 °C
- PSA：25.78000
- Density:1.286 g/cm3
- LogP:1.83150
4-Chloro-6-ethyl-5-fluoropyrimidine(Cas 137234-74-3) Usage
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Chemical Properties |
4-Chloro-6-ethyl-5-fluoropyrimidine is Yellow Liquid |
|
Uses |
4-Chloro-6-ethyl-5-fluoropyrimidine is a pyrimidine derivative used as a building block in the preparation of bio-active compounds such as broad-spectrum triazole antifungal agents. |
InChI:InChI=1/C6H6ClFN2/c1-2-4-5(8)6(7)10-3-9-4/h3H,2H2,1H3
137234-74-3 Relevant articles
Preparation method of 6-ethyl-5-fluoro-4-chloropyrimidine
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Paragraph 0033; 0048, (2020/06/20)
The invention provides a preparation met...
Voriconazole and intermediate preparation method
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Paragraph 0013; 0030-0041, (2019/05/15)
The present invention discloses a Vorico...
A 4 - (1-bromo-ethyl) - 5-fluoro-6-chloro-pyrimidine synthesis method
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Paragraph 0023; 0033; 0038; 0039, (2017/02/23)
The invention discloses a method for syn...
PROCESS FOR THE PREPARATION OF VORICONAZOLE
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Page/Page column 8, (2012/01/13)
The present invention provides a process...
137234-74-3 Process route
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- 137234-87-8
6-ethyl-5-fluoro-4-hydroxypyrimidine
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- 137234-74-3
4-chloro-6-ethyl-5-fluoropyrimidine
| Conditions | Yield |
|---|---|
|
6-ethyl-5-fluoro-4-hydroxypyrimidine; With triethylamine; trichlorophosphate; In dichloromethane; for 5.5h; Heating / reflux;
With hydrogenchloride; water; In dichloromethane; at 20 ℃;
|
95% |
|
With triethylamine; trichlorophosphate; In dichloromethane; at 40 ℃; for 8h; Reflux;
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90% |
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With trichlorophosphate; In N,N-dimethyl-formamide; at 90 ℃; for 5h;
|
90.2% |
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With trichlorophosphate; at 60 ℃; for 3h; Reagent/catalyst; Time; Temperature;
|
81% |
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6-ethyl-5-fluoro-4-hydroxypyrimidine; With triethylamine; trichlorophosphate; In dichloromethane; at 40 ℃; for 8h; Heating / reflux;
With hydrogenchloride; at 20 ℃;
|
|
|
With triethylamine; trichlorophosphate; In dichloromethane; at 5 - 55 ℃;
|
|
|
6-ethyl-5-fluoro-4-hydroxypyrimidine; With triethylamine; In dichloromethane; at 5 - 10 ℃;
With trichlorophosphate; In dichloromethane; at 10 - 55 ℃; for 8h; Reflux;
With hydrogenchloride; In dichloromethane; water; at 15 - 20 ℃; for 0.5h;
|
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- 188416-35-5
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
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- 86404-63-9
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
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- 137234-74-3
4-chloro-6-ethyl-5-fluoropyrimidine
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In water; at 60 - 70 ℃; Temperature; Reagent/catalyst; Solvent;
|
88.4% |
137234-74-3 Upstream products
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137234-87-8
6-Ethyl-5-fluoropyrimidin-4(3H)-one
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759-67-1
2-fluoro-3-oxopentanoic acid ethyl ester
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137234-87-8
6-ethyl-5-fluoro-4-hydroxypyrimidine
-
14989-30-1
hypochloric acid
137234-74-3 Downstream products
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137234-63-0
(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
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137234-62-9
voriconazole
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188416-35-5
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
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188416-28-6
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
Relevant Products
-
Nilotinib HClCAS：923288-90-8
-
VoriconazoleCAS：137234-62-9
-
7-methyl-2h-benzo[b][1,4]dioxepin-3(4h)-oneCAS：28940-11-6
