145202-66-0
- Product Name:Rizatriptan Benzoate
- Molecular Formula:C15H19N5
- Purity:99%
- Molecular Weight:391.473
Product Details;
CasNo: 145202-66-0
Molecular Formula: C15H19N5
Appearance: White to kind of white powder
Chinese Manufacturer Supply Sale Rizatriptan Benzoate 145202-66-0 Competitive Price
- Molecular Formula:C7H6O2*C15H19N5
- Molecular Weight:391.473
- Appearance/Colour:White to kind of white powder
- Vapor Pressure:2.58E-10mmHg at 25°C
- Melting Point:178-180 ºC
- Refractive Index:1.645
- Boiling Point:504.8 ºC at 760 mmHg
- Flash Point:259.1 ºC
- PSA:87.04000
- Density:1.21 g/cm3
- LogP:3.29660
Rizatriptan benzoate(Cas 145202-66-0) Usage
Description |
Known as a 5-hydroxytryptamine agonist, Rizatriptan Benzoate is the benzoate salt form of rizatriptan with anti-migraine activity, which can be used to treat the migraine headaches. It is FDA-approved to use in the treatment of acute migraine attacks with or without aura, especially taken at the first sign of a migraine headache. However, it cannot prevent future migraine attacks and it is ineffective to prevent other types of headache. The pain of migraine headaches is believed to be induced by dilated blood vessels inside the head. Rizatriptan Benzoate relieves the pain by inducing vasoconstriction, which functions as an agonist at serotonin 5-HT1B and 5-HT1D receptors. The selective receptor binding is effective to constrict cranial vessels and inhibit the transmission of nociception, thus providing relief of migraine headaches. |
Chemical Properties |
Off-White Solid |
Originator |
Merck & Co (US) |
Uses |
Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist and used to treat migraine (1,2,3). It is structurally derived from tryptamine. |
Brand name |
Maxalt (Merck). |
General Description |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Biochem/physiol Actions |
Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. |
InChI:InChI=1/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
145202-66-0 Relevant articles
Isotope-Edited Infrared Spectroscopy for Efficient Discrimination between Pharmaceutical Salts and Cocrystals
Iwata, Kentaro,Karashima, Masatoshi,Ikeda, Yukihiro
, p. 2350 - 2358 (2017/07/12)
Isotope-edited infrared spectroscopy usi...
Method for preparing the advantage grips Qu Tan a benzoic acid
-
Paragraph 0044-0046, (2017/02/09)
The invention discloses a novel preparat...
the advantage grips Qu Tan a method of preparing benzoic acid
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Paragraph 0056; 0057, (2016/10/07)
The invention discloses a novel method f...
NOVEL PROCESS
-
Page/Page column 7, (2010/10/19)
The present invention relates to a novel...
145202-66-0 Process route
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65-85-0,8013-63-6
benzoic acid
-
-
144034-80-0
rizatriptan
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-
145202-66-0
rizatriptan benzoate
Conditions | Yield |
---|---|
rizatriptan;
In
ethanol;
at 80 ℃;
for 0.333333h;
benzoic acid;
In
ethanol;
for 1.5h;
Reflux;
|
98.9% |
In
isopropyl alcohol;
|
95% |
In
Isopropyl acetate; isopropyl alcohol;
at 20 ℃;
for 0.5h;
|
80% |
In
isopropyl alcohol;
at 42 ℃;
for 1.25h;
|
63.8% |
In
ethanol; tert-butyl methyl ether;
for 1h;
|
24.6% |
In
methanol;
for 0.166667h;
Product distribution / selectivity;
Heating / reflux;
|
|
In
water;
at 60 - 70 ℃;
for 0.5h;
|
|
In
isopropyl alcohol;
for 0.166667h;
Product distribution / selectivity;
Heating / reflux;
|
|
In
tetrahydrofuran;
for 0.166667h;
Product distribution / selectivity;
Heating / reflux;
|
|
In
acetone;
for 0.166667h;
Product distribution / selectivity;
Heating / reflux;
|
|
In
isopropyl alcohol;
|
|
In
Isopropyl acetate; isopropyl alcohol;
at 25 - 30 ℃;
for 1h;
Product distribution / selectivity;
|
|
In
methanol; water;
at 20 ℃;
for 1h;
Product distribution / selectivity;
|
|
In
ethanol;
at 30 - 35 ℃;
pH=6.0 - 6.5;
|
|
In
acetone;
at 0 - 5 ℃;
for 3h;
|
|
In
ethanol; tert-butyl methyl ether;
for 1h;
Industry scale;
|
|
In
acetone;
at 0 - 30 ℃;
for 4.5 - 15.5h;
Product distribution / selectivity;
|
|
In
ethanol;
at 50 ℃;
for 2h;
|
|
In
methanol;
at 78 ℃;
|
-
-
65-85-0,8013-63-6
benzoic acid
-
-
144034-80-0
rizatriptan
-
-
3-[[3-[2-(N,N-dimethylamino)ethyl]-2-[[3-[2-(N,N-dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]methyl]-1H-1,2,4-triazole
-
-
145202-66-0
rizatriptan benzoate
Conditions | Yield |
---|---|
benzoic acid; rizatriptan;
In
acetone;
at 0 - 30 ℃;
for 4.5 - 15.5h;
With
potassium carbonate;
In
water;
pH=9 - 9.5;
Product distribution / selectivity;
|
145202-66-0 Upstream products
-
benzoic acid
-
rizatriptan
-
4-((1H-1,2,4-triazol-1-yl)methyl)-2-iodobenzenamine
-
2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethyl alcohol
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