What is the 5-Chloro-1-methyl-4-nitroimidazole?

5-Chloro-1-methyl-4-nitroimidazole is White solid, while it's Molecular Formula is C4H4ClN3O2. White solid 5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.

What is the CAS number for 5-Chloro-1-methyl-4-nitroimidazole?

The CAS number of 5-Chloro-1-methyl-4-nitroimidazole is 4897-25-0.

What is 5-Chloro-1-methyl-4-nitroimidazole (4897-25-0) used for?

5-Chloro-1-methyl-4-nitroimidazole is an intermediatein azathioprine synthesis, also present in the endproduct. It induced contact dermatitis in a manworking on azathioprine synthesis. Cross reactivity ispossible with imidazoles tioconazole, and econazole.InChI:InChI=1/C4H4ClN3O2/c1-7-2-6-4(3(7)5)8(9)10/h2H,1H3

Product classification

Hormones and steriods major pro

Medroxyprogesterone acetate intermediates

Progesterone intermediate

Cyproterone acetate intermediate

Deflazacort intermediate

Desogestrel intermediate

Finasteride intermediate
Major Products

Ubrogepant intermediate

Rimegepant intermediate

Indacaterol intermedaite

Dapagliflozin intermediate
Others

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4897-25-0

Product Name：1-Methyl-4-Nitro-5-Chloro Imidazole
Molecular Formula：C₄H₄ClN₃O₂
Purity：99%
Molecular Weight：161.548

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Product Details;

CasNo： 4897-25-0

Molecular Formula： C₄H₄ClN₃O₂

Appearance： White solid

Buy High Quality Reliable Quality 1-Methyl-4-Nitro-5-Chloro Imidazole 4897-25-0 Cheapest Price

Molecular Formula:C4H4ClN3O2
Molecular Weight:161.548
Appearance/Colour:White solid
Vapor Pressure:4.08E-05mmHg at 25°C
Melting Point:148-150 °C(lit.)
Refractive Index:1.648
Boiling Point:362.3 °C at 760 mmHg
PKA:-1.37±0.61(Predicted)
Flash Point:172.9 °C
PSA：63.64000
Density:1.65 g/cm³
LogP:1.50490

5-Chloro-1-methyl-4-nitroimidazole(Cas 4897-25-0) Usage

Description	5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide.
Chemical Properties	White Solid
Uses	5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.
General Description	5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.
Contact allergens	This intermediate in azathioprine synthesis is also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross-reactivity is possible with imidazoles tioconazole and econazole.

InChI:InChI=1/C4H4ClN3O2/c1-7-2-6-4(3(7)5)8(9)10/h2H,1H3

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4897-25-0 Process route

: 872-49-1
N-methyl-5-chloroimidazole

: 4897-25-0
5-chloro-1-methyl-4-nitroimidazole

Conditions

Conditions	Yield
With sulfuric acid; nitric acid; In water; Heating;	91%
With sulfuric acid; nitric acid; at 100 ℃; for 3.41667h; Inert atmosphere; Cooling with ice;	62%
With sulfuric acid; nitric acid;
With sulfuric acid; nitric acid; at 90 ℃; for 2h;
With sulfuric acid; nitric acid; In water; at 95 ℃; for 2h;