192569-17-8
- Product Name：11α-hydroxycanrenone
- Molecular Formula：C22H28O4
- Purity：99%
- Molecular Weight：356.462
Product Details;
CasNo： 192569-17-8
Molecular Formula： C22H28O4
Appearance： yellow crystalline solid
Factory Supply 11α-hydroxycanrenone 192569-17-8 Offer with Safe Transportation
- Molecular Formula:C22H28O4
- Molecular Weight:356.462
- Appearance/Colour:yellow crystalline solid
- Melting Point:232-234°C
- Refractive Index:1.598
- Boiling Point:584.7 °C at 760 mmHg
- PKA:14.55±0.60(Predicted)
- Flash Point:207.3 °C
- PSA：63.60000
- Density:1.25 g/cm3
- LogP:3.34090
11-alpha-Hydroxycarvenone(Cas 192569-17-8) Usage
|
Chemical Properties |
Yellow Crystalline Solid |
|
Uses |
11α-Hydroxy Canrenone is the key intermediate in the synthesis of Eplerenone, a cardiovascular drug. Canrenone was biotransformed into 11α-Hydroxycanrenone by Aspergillus ochraceus SIT34205. |
InChI:InChI=1/C22H28O4/c1-20-8-5-14(23)11-13(20)3-4-15-16-6-9-22(10-7-18(25)26-22)21(16,2)12-17(24)19(15)20/h3-4,11,15-17,19,24H,5-10,12H2,1-2H3/t15?,16?,17-,19?,20+,21+,22-/m1/s1
192569-17-8 Relevant articles
Development of a high-yielding bioprocess for 11-α hydroxylation of canrenone under conditions of oxygen-enriched air supply
Contente, Martina Letizia,Guidi, Benedetta,Serra, Immacolata,De Vitis, Valerio,Romano, Diego,Pinto, Andrea,Lenna, Roberto,de Souza Oliveira, Ricardo Pinheiro,Molinari, Francesco
, p. 1 - 4 (2016)
A high yielding bioprocess for 11-α hydr...
Structural characterization of 1β,11α-dihydroxycanrenone biotrans-formed from canrenone by Aspergillus ochraceus SIT34205
Rong, Shao Feng,Zhang, Xiao Li,Ding, Bao Mei,Wang, Yi Fei,Pan, Xian Hua,Zhang, Jian,Shen, Yi
experimental part, p. 313 - 316 (2012/05/05)
Canrenone (1) was biotransformed into 11...
Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein
-
Page 75, (2008/06/13)
Multiple novel reaction schemes, novel p...
192569-17-8 Process route
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- 976-71-6
canrenone
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- 192569-17-8
11α-hydroxyl canrenone
| Conditions | Yield |
|---|---|
|
With D-glucose; peptone; In water;
|
90% |
|
With D-glucose; In water; for 72h;
|
80% |
|
With D-glucose; In water; for 72h;
|
80% |
|
With D-glucose; peptone; In water;
|
80% |
|
With ammonium dihydrogen phosphate; sodium hydroxide; D-glucose; L-Cephalexin; Tetracycline hydrochloride; peptone; yeast extract; In water; for 73.5 - 122h; pH=6.5;
|
60% |
|
With D-glucose; peptone; In water;
|
50% |
|
With D-glucose; In water; for 72h;
|
50% |
|
With D-glucose; peptone; In water;
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50% |
|
With ammonium dihydrogen phosphate; sodium hydroxide; D-glucose; In methanol; water; for 104 - 166h; pH=6 - 6.5;
|
45.9% |
|
With D-glucose; peptone; In water;
|
10% |
|
With D-glucose; peptone; In water;
|
5% |
|
With D-glucose; peptone; In water;
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5% |
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With D-glucose; peptone; In water;
|
5% |
|
With malt extract; D-glucose; L-Cephalexin; Tetracycline hydrochloride; peptone; yeast extract; In water; at 25 ℃; for 96h; pH=4.5 - 6;
|
|
|
With ammonium dihydrogen phosphate; sodium hydroxide; dipotassium hydrogenphosphate; D-glucose; corn steep liquor; ammonia; L-Cephalexin; Tetracycline hydrochloride; glycerol; peptone; yeast extract; In water; at 24 - 121 ℃; for 110 - 130h; pH=5.2 - 6.5;
|
|
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With air; D-glucose; L-Cephalexin; Tetracycline hydrochloride; peptone; In water; at 24 - 28 ℃; for 90h; under 220.672 Torr; pH=4.7 - 5.3;
|
60 g |
|
With air; D-glucose; L-Cephalexin; Tetracycline hydrochloride; peptone; In water; at 24 - 28 ℃; for 96h; under 367.786 Torr; pH=4.7 - 5.3;
|
14 kg |
|
With D-glucose; peptone; yeast extract; In water; for 80 - 160h;
|
|
|
With oxygen; In dimethyl sulfoxide; Microbiological reaction;
|
-
- 976-71-6
canrenone
-
- 192569-17-8
11α-hydroxyl canrenone
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- 1363502-03-7
C22H28O5
| Conditions | Yield |
|---|---|
|
With Aspergillus ochraceus SIT34205; at 28 ℃; for 50h;
|
192569-17-8 Upstream products
-
976-71-6
canrenone
192569-17-8 Downstream products
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192704-54-4
4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
-
107724-20-9
eplerenone
-
192704-56-6
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
-
192704-58-8
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
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