57149-07-2

  • Product Name:Naftopidil
  • Molecular Formula:C24H28N2O3
  • Purity:99%
  • Molecular Weight:392.498
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Product Details;

CasNo: 57149-07-2

Molecular Formula: C24H28N2O3

Appearance: Off-White Solid

Chinese Manufacturer Supply Wholesale Naftopidil 57149-07-2 On Stock

  • Molecular Formula:C24H28N2O3
  • Molecular Weight:392.498
  • Appearance/Colour:Off-White Solid 
  • Vapor Pressure:2.22E-15mmHg at 25°C 
  • Melting Point:127 °C 
  • Refractive Index:1.6300 (estimate) 
  • Boiling Point:602.8 °C at 760 mmHg 
  • PKA:14.01±0.20(Predicted) 
  • Flash Point:318.3 °C 
  • PSA:45.17000 
  • Density:1.184 g/cm3 
  • LogP:3.41320 

Naftopidil dihydrochloride(Cas 57149-07-2) Usage

Description

Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.

Chemical Properties

Off-White Solid

Originator

Boehringer Mannheim (Germany)

Uses

Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

Brand name

Avishot;Flivas

Biological Activity

An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.

InChI:InChI=1/C24H28N2O3.2ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;2*1H

57149-07-2 Relevant articles

NAFTOPIDIL MONOHYDROCHLORIDE DIHYDRATE AND USE THEREOF FOR PREPARATION OF NAFTOPIDIL

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, (2021/07/27)

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Paragraph 0064-0066, (2017/04/03)

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NOVEL ANTICANCER AGENT

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Paragraph 0179-0181, (2015/12/30)

The present invention aims to provide a ...

57149-07-2 Process route

3-(1-naphthyloxy)-1,2-epoxypropane
2461-42-9

3-(1-naphthyloxy)-1,2-epoxypropane

1-(2-Methoxyphenyl)piperazine
35386-24-4

1-(2-Methoxyphenyl)piperazine

naftopidil
57149-07-2

naftopidil

Conditions
Conditions Yield
In ethanol; for 1h; Reflux;
100%
In ethanol; at 20 ℃; for 1h;
100%
With zinc(II) perchlorate hexahydrate; In dichloromethane; at 20 ℃; for 16h;
92%
With zinc(II) perchlorate; In water; at 140 ℃; for 0.166667h; under 5250.53 Torr; Flow reactor;
95 %Chromat.
(2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride
1164469-60-6,57149-08-3

(2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride

naftopidil
57149-07-2

naftopidil

Conditions
Conditions Yield
With water; sodium hydroxide; In toluene; Reagent/catalyst;
90%

57149-07-2 Upstream products

  • 2461-42-9
    2461-42-9

    3-(1-naphthyloxy)-1,2-epoxypropane

  • 35386-24-4
    35386-24-4

    1-(2-Methoxyphenyl)piperazine

  • 90-15-3
    90-15-3

    α-naphthol

  • 90-04-0
    90-04-0

    2-methoxy-phenylamine

57149-07-2 Downstream products

  • 133347-36-1
    133347-36-1

    O-desmethyl-naftopidil

  • 133024-36-9
    133024-36-9

    (naphthyl)hydroxy-naftopidil

  • 133024-35-8
    133024-35-8

    (phenyl)hydroxy-naftopidil

  • 117067-06-8
    117067-06-8

    3-<4-(2-Methoxyphenyl)piperazinyl>-1,2-propandiol

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