100331-89-3

  • Product Name：8-benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
  • Molecular Formula：C18H14BrNO3
  • Purity：99%
  • Molecular Weight：372.218
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Product Details;

CasNo： 100331-89-3

Molecular Formula： C18H14BrNO3

Appearance： Off-white solid

Buy High Quality High Purity 8-benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline 100331-89-3 Safe Transportation

  • Molecular Formula:C18H14BrNO3
  • Molecular Weight:372.218
  • Appearance/Colour:Off-white solid 
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.638 
  • Boiling Point:602.645 °C at 760 mmHg 
  • PKA:10.38±0.70(Predicted) 
  • Flash Point:318.268 °C 
  • PSA：59.42000 
  • Density:1.48 g/cm3 
  • LogP:4.09700 

8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE(Cas 100331-89-3) Usage

Chemical Properties

Off-white Solid

Uses

8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one can be used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

InChI:InChI=1/C18H14BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,20,22)

100331-89-3 Relevant articles

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

Rancati, Fabio,Linney, Ian D.,Rizzi, Andrea,Delcanale, Maurizio,Knight, Chris K.,Schmidt, Wolfgang,Pastore, Fiorella,Riccardi, Benedetta,Mileo, Valentina,Carnini, Chiara,Cesari, Nicola,Blackaby, Wesley P.,Patacchini, Riccardo,Carzaniga, Laura

supporting information, (2021/04/12)

The targeting of both the muscarinic and...

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

-

Paragraph 0159, (2019/11/11)

The invention provides a class of compou...

Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives

Woo, Anthony Yiu-Ho,Ge, Xin-yue,Pan, Li,Xing, Gang,Mo, Yong-mei,Xing, Rui-juan,Li, Xiao-ran,Zhang, Yu-yang,Wainer, Irving W.,Cheng, Mao-sheng,Xiao, Rui-ping

, p. 1095 - 1105 (2019/01/19)

β-Arrestins are a small family of protei...

A Process for Preparing Indacaterol and Salts Thereof

-

Paragraph 0070, (2018/08/20)

The present invention relates to a proce...

100331-89-3 Process route

5-acetyl-8-benzyloxy-1H-quinolin-2-one
93609-84-8

5-acetyl-8-benzyloxy-1H-quinolin-2-one

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
100331-89-3

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

Conditions
Conditions Yield
With aluminum (III) chloride; bromine; In dichloromethane; at 0 - 20 ℃; for 4.5h;
82.9%
With bromine; trifluoroborane diethyl ether; potassium carbonate; In dichloromethane;
75.7%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetra-N-butylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
With tetrabutylammomium bromide; In tetrahydrofuran; methanol; at 20 ℃;
73%
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃;
With bromine; In dichloromethane; at 45 ℃; for 0.916667h;
With sodium carbonate; In water; for 1h;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃;
With bromine; In dichloromethane; at 45 ℃; for 0.916667h;
 
With bromine; trifluoroborane diethyl ether; In dichloromethane; at 0 - 45 ℃; for 0.25h;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With tetrabuthylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃; for 18.5h;
With water; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;
 
With boron trifluoride diethyl etherate; bromine; In dichloromethane; at 0 - 45 ℃; for 0.916667h;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃;
With bromine; In dichloromethane; at 45 ℃; for 0.916667h;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; bromine; In dichloromethane; at 0 - 45 ℃; for 0.916667h;
With sodium carbonate; In water; for 1h;
 
With N-Bromosuccinimide; In chloroform;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 45 ℃;
With bromine; In dichloromethane; at 45 ℃; for 0.916667h;
 
With boron trifluoride diethyl etherate; bromine; In dichloromethane; at 0 - 45 ℃; for 0.916667h;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With trifluoroborane diethyl ether; In dichloromethane; at 0 - 20 ℃;
With bromine; In dichloromethane; at 20 - 45 ℃; for 0.916667h;
 
With pyridinium hydrobromide perbromide; In tetrahydrofuran; at 0 ℃; Reflux;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.166667h;
With bromine; In dichloromethane; for 2.75h; Reflux;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.25h;
With bromine; In dichloromethane; at 20 - 40 ℃; for 0.916667h;
 
5-acetyl-8-benzyloxy-1H-quinolin-2-one; With boron trifluoride diethyl etherate; In dichloromethane; Heating / reflux;
With bromine; In dichloromethane; for 4.5h; Heating / reflux;
With water; potassium carbonate; In dichloromethane; at 30 ℃; pH=8 - 9;
 
With boron trifluoride diethyl etherate; bromine; In dichloromethane; for 0.25h; Reflux;
 
tetra-n-butylammonium tribromide

tetra-n-butylammonium tribromide

5-acetyl-8-benzyloxy-1H-quinolin-2-one
93609-84-8

5-acetyl-8-benzyloxy-1H-quinolin-2-one

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
100331-89-3

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

Conditions
Conditions Yield
In tetrahydrofuran; methanol;
73%

100331-89-3 Upstream products

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    93609-84-8

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  • 148-24-3
    148-24-3

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    15450-72-3

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100331-89-3 Downstream products

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    8-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one

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    biphenyl-2-ylcarbamic Acid 1-[2-(4-{[(R)-2-(tert-Butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-2-chloro-5-methoxy-phenylcarbamoyl)ethyl]piperidin-4-yl Ester

  • 1042738-15-7
    1042738-15-7

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