24356-94-3
- Product Name：Algestone Acetophenide
- Molecular Formula：C29H36O4
- Purity：99%
- Molecular Weight：448.602
Product Details;
CasNo： 24356-94-3
Molecular Formula： C29H36O4
Chinese Factory Supply Algestone Acetophenide 24356-94-3 Export On Stock
- Molecular Formula:C29H36O4
- Molecular Weight:448.602
- Vapor Pressure:2.11E-13mmHg at 25°C
- Melting Point:150 - 151ºC
- Refractive Index:1.59
- Boiling Point:579 °C at 760 mmHg
- Flash Point:246.7 °C
- PSA：52.60000
- Density:1.19 g/cm3
- LogP:5.74430
Algestone acetophenide(Cas 24356-94-3) Usage
|
Originator |
Neolutin Depo, Medici ,Italy ,1982 |
|
Uses |
Progestin. |
|
Manufacturing Process |
To a suspension of 500 mg of 16α,17α-dihydroxyprogesterone in 25 ml of freshly redistilled acetophenone is added 0.125 ml of 72% perchloric acid and the mixture is agitated at room temperature for one hour. The clear solution is washed with dilute sodium bicarbonate to remove excess acid and the acetophenone layer, after addition of chloroform is separated from the aqueous phase. The organic layer is dried over sodium sulfate and after removal of the chloroform and acetophenone in high vacuum the residue is crystallized from 95% alcohol. The pure acetophenone derivative has a melting point of about 142°C to 144°C. |
|
Brand name |
Deladroxone (Bristol-Myers Squibb); Droxone (Bristol-Myers Squibb). |
|
Therapeutic Function |
Progestin, Contraceptive |
InChI:InChI=1/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1
24356-94-3 Process route
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![(6bS,9aR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one](/upload/2023/9/c8c55b9c-0a91-4410-82cb-a60bd37187dc.png)
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1179-87-9,24356-94-3,147201-97-6
(6bS,9aR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one
| Conditions | Yield |
|---|---|
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Di-OH-Verb. 1, Carbonylverb.;
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Alkohol III durch Oxidation;
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Dibromid IV;
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