122536-94-1
- Product Name：(S)-3-hydroxypyrrolidine hydrochloride
- Molecular Formula：C4H9NO.HCl
- Purity：99%
- Molecular Weight：123.582
Product Details;
CasNo： 122536-94-1
Molecular Formula： C4H9NO.HCl
Appearance： white crystalline powder
Chinese Factory Supply Top Purity 99% (S)-3-hydroxypyrrolidine hydrochloride 122536-94-1 Competitive Price
- Molecular Formula:C4H9NO.HCl
- Molecular Weight:123.582
- Appearance/Colour:white crystalline powder
- Vapor Pressure:0.018mmHg at 25°C
- Melting Point:104-107 °C
- Boiling Point:224.7 °C at 760 mmHg
- Flash Point:105.8 °C
- PSA：32.26000
- LogP:0.47140
(S)-3-Hydroxypyrrolidine hydrochloride(Cas 122536-94-1) Usage
|
Chemical Properties |
almost white crystalline powder |
|
Uses |
(S)-3-Hydroxypyrrolidine Hydrochloride is a useful intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function. |
InChI:InChI=1/C4H9NO.ClH/c6-4-1-2-5-3-4;/h4-6H,1-3H2;1H/t4-;/m0./s1
122536-94-1 Relevant articles
Synthesis method of (S)-3-pyrrolidinol hydrochloride
-
Paragraph 0023; 0026-0028; 0031-0032; 0038-0040, (2020/08/27)
The invention discloses a synthesis meth...
Preparation method of (S)-3-hydroxypyrrolidine hydrochloride
-
Paragraph 0031; 0032, (2016/11/09)
The invention relates to the field of ch...
POLYCYCLIC DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF
-
Paragraph 0224; 0225, (2015/02/05)
Disclosed in the present invention are p...
POLYCYCLIC DERIVATIVES, PREPARATION METHOD AND MEDICAL USES THEREOF
-
Paragraph 0153; 0154, (2014/12/09)
Disclosed in the present invention are p...
122536-94-1 Process route
-
-
101469-91-4
(3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione
-
-
122536-94-1,111810-68-5
(S)-3-hydroxypyrrolidine hydrochloride
| Conditions | Yield |
|---|---|
|
(3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione;
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
at 75 ℃;
for 5h;
under 4125.41 Torr;
Autoclave;
With
hydrogenchloride;
In
isopropyl alcohol;
at 20 ℃;
Temperature;
Pressure;
|
88% |
-
-
101469-92-5,83220-73-9
(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
-
-
122536-94-1,111810-68-5
(S)-3-hydroxypyrrolidine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
1,4-dioxane;
for 0.5h;
|
|
|
With
hydrogenchloride;
In
1,4-dioxane;
for 0.5h;
Inert atmosphere;
|
|
|
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
for 12h;
|
21 g |
122536-94-1 Upstream products
-
127913-44-4
(S)-4-chloro-3-hydroxy butyronitrile
-
101469-92-5
(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
-
101469-91-4
(3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione
122536-94-1 Downstream products
-
207847-98-1
ethyl ((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-2-oxo-1-phenylethyl)
-
477779-12-7
(S)-3-Hydroxy-1-(4-pyrrolidinophenethyl)pyrrolidine
-
100858-32-0
(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester
-
100858-33-1
(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
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